Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hgftm1Cbm
Name:	hepatocyte growth factor; targeted mutation 1, Carmen Birchmeier
MGI ID:	MGI:1857656
Synonyms:	SF/HGF-
Gene:	Hgf  Location: Chr5:16758493-16825150 bp, + strand  Genetic Position: Chr5, 7.07 cM, cytoband A2-A3
Alliance:	Hgftm1Cbm page

Germline Transmission:	Earliest citation of germline transmission: J:23170
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Deletion of exon 2, which encodes amino acids 31 to 84 of the receptor binding domain, and replacement of these sequences with a neomycin cassette. (J:23170) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hgf Mutation:	55 strains or lines available

Original:	J:23170 Schmidt C, et al., Scatter factor/hepatocyte growth factor is essential for liver development. Nature. 1995 Feb 23;373(6516):699-702
All:	5 reference(s)