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Cbx2tm1Cim
Targeted Allele Detail
Summary
Symbol: Cbx2tm1Cim
Name: chromobox 2; targeted mutation 1, Centre d'Immunologie de Marseille Luminy
MGI ID: MGI:1857631
Synonyms: M33 -
Gene: Cbx2  Location: Chr11:118913845-118922101 bp, + strand  Genetic Position: Chr11, 83.33 cM
Alliance: Cbx2tm1Cim page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38487
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exons 1-4. RT-PCR analysis confirmed the absence of the transcript in homozygous mice. (J:38487)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 62 assay results
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Cbx2 Mutation:  38 strains or lines available
References
Original:  J:38487 Core N, et al., Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice. Development. 1997 Feb;124(3):721-9
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory