Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ptk2tm1Imeg
Name:	PTK2 protein tyrosine kinase 2; targeted mutation 1, Institute of Molecular Embryology and Genetics
MGI ID:	MGI:1857596
Synonyms:	FAK-
Gene:	Ptk2  Location: Chr15:73076951-73295129 bp, - strand  Genetic Position: Chr15, 33.94 cM
Alliance:	Ptk2tm1Imeg page

Germline Transmission:	Earliest citation of germline transmission: J:29273
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance cassette was inserted into sequences encoding the beginning of the kinase domain. Western blot analysis of lysates derived from E8.5 embryos demonstrated that the protein was absent in homozygotes. (J:29273)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	32 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptk2 Mutation:	90 strains or lines available

Original:	J:29273 Ilic D, et al., Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature. 1995 Oct 12;377(6549):539-44
All:	14 reference(s)