Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Runx1tm1Dow
Name:	runt related transcription factor 1; targeted mutation 1, James R Downing
MGI ID:	MGI:1857580
Synonyms:	AML-, AML1-, Runx1-
Gene:	Runx1  Location: Chr16:92398354-92622962 bp, - strand  Genetic Position: Chr16, 53.7 cM
Alliance:	Runx1tm1Dow page

Germline Transmission:	Earliest citation of germline transmission: J:31130
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A hygromycin B expression cassette replaced the splice acceptor site and the first 20 bp of the exon that encodes the central 52 amino acids of the Runt homology domain (RHD). RT-PCR analysis on RNA derived from whole E11.5 embryos did not detect any transcript in homozygous mice. (J:31130)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	16 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx1 Mutation:	35 strains or lines available

Original:	J:31130 Okuda T, et al., AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell. 1996 Jan 26;84(2):321-30
All:	11 reference(s)