Tal1tm1Wehi
Targeted Allele Detail
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Symbol: |
Tal1tm1Wehi |
Name: |
T cell acute lymphocytic leukemia 1; targeted mutation 1, Walter and Eliza Hall Institute of Medical Research |
MGI ID: |
MGI:1857566 |
Synonyms: |
scl- |
Gene: |
Tal1 Location: Chr4:114913623-114928952 bp, + strand Genetic Position: Chr4, 52.73 cM
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Alliance: |
Tal1tm1Wehi page
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Appearance and histology of Tal1tm1Wehi/Tal1tm1Wehi embryos
Show the 1 phenotype image(s) involving this allele.
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Two targeting vectors were used to create two targeted mutations, but these were not distinguished in the paper. Vector 582 disrupted the Tal1 gene by replacing the sequences encoding the b-HLH domain with a neomycin gene. Vector 607 disrupted the Tal1 gene by replacing the sequences encoding the b-HLH domain with a hygromycin gene.
(J:27458)
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Inheritance: |
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Recessive |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tal1 Mutation: |
33 strains or lines available
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Original: |
J:27458 Robb L, et al., Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):7075-9 |
All: |
7 reference(s) |
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