Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Krastm1Mok
Name:	Kirsten rat sarcoma viral oncogene homolog; targeted mutation 1, Motoya Katsuki
MGI ID:	MGI:1857551
Synonyms:	K-ras-
Gene:	Kras  Location: Chr6:145162425-145195965 bp, - strand  Genetic Position: Chr6, 77.37 cM, cytoband G2
Alliance:	Krastm1Mok page

Germline Transmission:	Earliest citation of germline transmission: J:42943
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin cassette replaces the 3' part of exon 1, which encodes a part of the effector domain essential for K-ras activity. (J:42943)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Kras Mutation:	76 strains or lines available

Original:	J:42943 Koera K, et al., K-ras is essential for the development of the mouse embryo. Oncogene. 1997 Sep 4;15(10):1151-9
All:	3 reference(s)