Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Map2k4tm1Pngr
Name:	mitogen-activated protein kinase kinase 4; targeted mutation 1, Josef M Penninger
MGI ID:	MGI:1857536
Synonyms:	Epha4tm1Oci, Sek1 -
Gene:	Map2k4  Location: Chr11:65579069-65679123 bp, - strand  Genetic Position: Chr11, 40.53 cM
Alliance:	Map2k4tm1Pngr page

Germline Transmission:	Earliest citation of germline transmission: J:77942
Parent Cell Line:	E14K (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2 was disrupted by the insertion of a neomycin selection cassette. Neither transcript nor protein was detected in homozygous mutant ES cells. (J:77942)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

16 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Map2k4 Mutation:	32 strains or lines available

Original:	J:77942 Nishina H, et al., Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature. 1997 Jan 23;385(6614):350-3
All:	7 reference(s)