Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gli2tm1Alj
Name:	GLI-Kruppel family member GLI2; targeted mutation 1, Alexandra L Joyner
MGI ID:	MGI:1857509
Synonyms:	Gli2-, Gli2zfd
Gene:	Gli2  Location: Chr1:118761862-118981349 bp, - strand  Genetic Position: Chr1, 52.17 cM, cytoband E2-E4
Alliance:	Gli2tm1Alj page

Germline Transmission:	Earliest citation of germline transmission: J:38381
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced 2.4 kb of the gene, resulting in the deletion of exons that encode the zinc fingers 3 - 5 of the protein and 71 amino acid residues carboxyl to these zinc fingers. (J:38381, J:49164)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	603 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	52 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gli2 Mutation:	169 strains or lines available

Original:	J:38381 Mo R, et al., Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development. 1997 Jan;124(1):113-23
All:	118 reference(s)