Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rbl2tm1Mru
Name:	RB transcriptional corepressor like 2; targeted mutation 1, Michael Rudnicki
MGI ID:	MGI:1857500
Synonyms:	p130-
Gene:	Rbl2  Location: Chr8:91796685-91850472 bp, + strand  Genetic Position: Chr8, 44.25 cM
Alliance:	Rbl2tm1Mru page

Germline Transmission:	Earliest citation of germline transmission: J:50516
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Insertion of a PGK neomycin resistance cassette into an exon disrupted the Rbl2 gene. Northern analysis of homozygous mutant embryos (E14) using a full length Rbl2 cDNA probe did not detect Rbl2 mRNA. Immunoblot analysis using antisera reactive with the carboxyl-terminal 20 amino acids of RBL2 did not detect RBL2 in homozygous mutant embryos. (J:50516)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rbl2 Mutation:	52 strains or lines available

Original:	J:50516 LeCouter JE, et al., Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene. Development. 1998 Dec;125(23):4669-79
All:	2 reference(s)