Sod2tm1Leb
Targeted Allele Detail
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Symbol: |
Sod2tm1Leb |
Name: |
superoxide dismutase 2, mitochondrial; targeted mutation 1, Russell M Lebovitz |
MGI ID: |
MGI:1857480 |
Synonyms: |
Sod2-, SOD2m1BCM, Sod2mlbcm |
Gene: |
Sod2 Location: Chr17:13226726-13237006 bp, + strand Genetic Position: Chr17, 8.75 cM
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Alliance: |
Sod2tm1Leb page
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Histological abnormalities in Sod2tm1Leb/Sod2tm1Leb mice
Show the 2 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:36148
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Parent Cell Line: |
AB2.1 (ES Cell)
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Strain of Origin: |
129S7/SvEvBrd-Hprt1b-m2
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A human HPRT minigene driven by the PGK promoter replaced exons 1 and 2, and sequences approximately 500 bp immediately 5' of exon 1. The replaced region encodes the transcription and translation start sites, the mitochondrial targeting sequence, and one of three histidines that bind directly to the manganese cofactor. Northern blot analysis of brain did not detect mRNA in homozygous mutant mice. Enzyme activity assays of heart did not detect active protein in homozygous mutant mice.
(J:36148)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:36148 Lebovitz RM, et al., Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9782-7 |
All: |
44 reference(s) |
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