Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Rbl2tm1Tyj
Name:	RB transcriptional corepressor like 2; targeted mutation 1, Tyler Jacks
MGI ID:	MGI:1857449
Synonyms:	p130-
Gene:	Rbl2  Location: Chr8:91796685-91850472 bp, + strand  Genetic Position: Chr8, 44.25 cM
Alliance:	Rbl2tm1Tyj page

Germline Transmission:	Earliest citation of germline transmission: J:34725
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced sequences in a proximal exon of the Rbl2 gene. Rbl2 mRNA levels in liver cells of homozygous mutant animals were reduced more than five fold compared to wild-type. Immunoblot analysis did not detect RBL2 protein in embryonic fibroblasts or in adult liver of homozygous mutant mice. (J:34725)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

126 assay results

List all tumor models in MMHCdb carrying Rbl2tm1Tyj

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rbl2 Mutation:	52 strains or lines available

Original:	J:34725 Cobrinik D, et al., Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev. 1996 Jul 1;10(13):1633-44
All:	31 reference(s)