Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Col3a1tm1Jae Name: collagen, type III, alpha 1; targeted mutation 1, Rudolf Jaenisch MGI ID: MGI:1857431 Gene: Col3a1  Location: Chr1:45350698-45388866 bp, + strand  Genetic Position: Chr1, 23.67 cM Alliance: Col3a1tm1Jae page

Col3a1tm1Jae/Col3a1tm1Jae mouse with skin lesion Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:39273
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced a genomic fragment containing the promoter region and first exon of the gene. Protein analysis of isolated tail and skin collagens from homozygous mice demonstrated that no stable protein was produced from this allele. (J:39273)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Col3a1 Mutation:	85 strains or lines available

Original:	J:39273 Liu X, et al., Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1852-6 SS 18 /C?
All:	9 reference(s)