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Rasa1tm1Paw
Targeted Allele Detail
Summary
Symbol: Rasa1tm1Paw
Name: RAS p21 protein activator 1; targeted mutation 1, Tony Pawson
MGI ID: MGI:1857417
Gene: Rasa1  Location: Chr13:85362899-85437249 bp, - strand  Genetic Position: Chr13, 45.05 cM
Alliance: Rasa1tm1Paw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:29825
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin cassette replaced a genomic fragment containing sequences encoding the N-terminal SH2 domain. Western blot analysis of total embryo protein lysates showed that no RASA1 protein was produced in homozygous mice. (J:29825)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rasa1 Mutation:  34 strains or lines available
References
Original:  J:29825 Henkemeyer M, et al., Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein. Nature. 1995 Oct 26;377(6551):695-701
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory