Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Rb1tm1Mlh
Name:	RB transcriptional corepressor 1; targeted mutation 1, Martin L Hooper
MGI ID:	MGI:1857340
Synonyms:	Rb-, Rbt19hyg
Gene:	Rb1  Location: Chr14:73430298-73563446 bp, - strand  Genetic Position: Chr14, 38.73 cM, cytoband D3
Alliance:	Rb1tm1Mlh page

Germline Transmission:	Earliest citation of germline transmission: J:2498
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Insertion of a hygromycin resistance cassette into exon 19 disrupted the Rb1 gene. The authors predict that the Rb1 reading frame would be truncated upstream of the coding sequence for T-antigen binding domain number 2, and that therefore any gene product will be non functional. (J:2498)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

9 anatomical structure(s)

List all tumor models in MMHCdb carrying Rb1tm1Mlh

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rb1 Mutation:	106 strains or lines available

Original:	J:2498 Clarke AR, et al., Requirement for a functional Rb-1 gene in murine development [see comments]. Nature. 1992 Sep 24;359(6393):328-30
All:	4 reference(s)