Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	F2rtm1Ajc
Name:	coagulation factor II thrombin receptor; targeted mutation 1, Andrew J Connolly
MGI ID:	MGI:1857306
Synonyms:	Par1-, Par1-, PAR-1-, tr-
Gene:	F2r  Location: Chr13:95738311-95754995 bp, - strand  Genetic Position: Chr13, 50.21 cM
Alliance:	F2rtm1Ajc page

Germline Transmission:	Earliest citation of germline transmission: J:33380
Parent Cell Line:	RF8 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced sequences in exon 2 encoding transmembrane domains 1-7. Northern blot analysis on RNA derived from E12 embryos and from embryonic fibroblasts demonstrated that no detectable transcript was produced from this allele. Furthermore, transcripts from this allele were not detected in various tissues of adult homozygous mice (data not shown). (J:33380)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any F2r Mutation:	23 strains or lines available

Original:	J:33380 Connolly AJ, et al., Role of the thrombin receptor in development and evidence for a second receptor. Nature. 1996 Jun 6;381(6582):516-9
All:	72 reference(s)