Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Icam1tm1Jcgr
Name:	intercellular adhesion molecule 1; targeted mutation 1, Jose Carlos Gutierrez Ramos
MGI ID:	MGI:1857292
Synonyms:	ICAM-1-, ICAM-1-deficient, ICAMtm1-jcgr
Gene:	Icam1  Location: Chr9:20927281-20940113 bp, + strand  Genetic Position: Chr9, 7.69 cM
Alliance:	Icam1tm1Jcgr page

Germline Transmission:	Earliest citation of germline transmission: J:18743
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance cassette was inserted into exon 4 of the gene. While King, et. al. (J:25530) reported the potential for the production of functional proteins arising from alternative transcripts, corresponding signals were undetected by immunohistochemical analysis of homozygous mutant mice. (J:18743)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Icam1 Mutation:	24 strains or lines available

Original:	J:18743 Xu H, et al., Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice. J Exp Med. 1994 Jul 1;180(1):95-109
All:	90 reference(s)