Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Cyp7a1tm1Rus Name: cytochrome P450, family 7, subfamily a, polypeptide 1; targeted mutation 1, David W Russell MGI ID: MGI:1857285 Synonyms: Cyp7-, CYP7A1- Gene: Cyp7a1  Location: Chr4:6265612-6275632 bp, - strand  Genetic Position: Chr4, 2.91 cM Alliance: Cyp7a1tm1Rus page

Oily coat phenotype of Cyp7a1tm1Rus/Cyp7a1tm1Rus nursing mothers and pups Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:34342
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing part of exon 3, exon 4 and exon 5 was replaced with a neomycin selection cassette. Activity assays on extracts of liver microsomal memebrane preparations derived from homozygous mice demonstrated that no functional protein is made from this allele. (J:34342)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cyp7a1 Mutation:	34 strains or lines available

Original:	J:34342 Ishibashi S, et al., Disruption of cholesterol 7alpha-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation. J Biol Chem. 1996 Jul 26;271(30):18017-23
All:	17 reference(s)