Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Yes1tm1Sor
Name:	YES proto-oncogene 1, Src family tyrosine kinase; targeted mutation 1, Philippe Soriano
MGI ID:	MGI:1857269
Synonyms:	p62YesKO, yes-, yes neo
Gene:	Yes1  Location: Chr5:32768515-32844401 bp, + strand  Genetic Position: Chr5, 17.33 cM
Alliance:	Yes1tm1Sor page

Germline Transmission:	Earliest citation of germline transmission: J:20346
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The yes gene was disrupted by insertion of a neomycin cassette into exon 7, which encodes the beginning of the kinase domain. A partial protein product has been reported in some cell types (see J:54973). (J:20346) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

6 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Yes1 Mutation:	137 strains or lines available

Original:	J:20346 Stein PL, et al., Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice. Genes Dev. 1994 Sep 1;8(17):1999-2007
All:	16 reference(s)