Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tgfb3tm1Doe
Name:	transforming growth factor, beta 3; targeted mutation 1, Thomas Doetschman
MGI ID:	MGI:1857259
Synonyms:	TGF-beta3 null
Gene:	Tgfb3  Location: Chr12:86103519-86125815 bp, - strand  Genetic Position: Chr12, 40.09 cM
Alliance:	Tgfb3tm1Doe page

Germline Transmission:	Earliest citation of germline transmission: J:29901
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced exon 6, which encodes the active domain of the protein. RT-PCR analysis of RNA derived from whole E11.5 or E15.5 embryos did not detect any transcript produced from this allele in homozygous mice. (J:29901)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	78 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tgfb3 Mutation:	34 strains or lines available

Original:	J:29901 Proetzel G, et al., Transforming growth factor-beta 3 is required for secondary palate fusion. Nat Genet. 1995 Dec;11(4):409-14
All:	42 reference(s)