Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tal1tm1Sho
Name:	T cell acute lymphocytic leukemia 1; targeted mutation 1, Stuart Orkin
MGI ID:	MGI:1857254
Synonyms:	SCL, tal-1-
Gene:	Tal1  Location: Chr4:114913623-114928952 bp, + strand  Genetic Position: Chr4, 52.73 cM
Alliance:	Tal1tm1Sho page

Germline Transmission:	Earliest citation of germline transmission: J:23061
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Replacement of coding sequences of the Tal1 gene, including the bHLH sequences, with a neomycin cassette. (J:23061) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	8 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tal1 Mutation:	33 strains or lines available

Original:	J:23061 Shivdasani RA, et al., Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature. 1995 Feb 2;373(6513):432-4
All:	7 reference(s)