Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Syn2tm1Sud
Name:	synapsin II; targeted mutation 1, Thomas C Sudhof
MGI ID:	MGI:1857251
Synonyms:	Syn II KO
Gene:	Syn2  Location: Chr6:115111863-115258967 bp, + strand  Genetic Position: Chr6, 53.2 cM, cytoband F
Alliance:	Syn2tm1Sud page

Germline Transmission:	Earliest citation of germline transmission: J:26920
Parent Cell Line:	JH1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance gene was inserted to replace exons 9 and 10. A lack of protein expression in homozygous mutant mice was observed using immunoblot analysis. (J:26920)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Syn2 Mutation:	22 strains or lines available

Original:	J:26920 Rosahl TW, et al., Essential functions of synapsins I and II in synaptic vesicle regulation [see comments]. Nature. 1995 Jun 8;375(6531):488-93
All:	16 reference(s)