Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Oxttm1Wsy
Name:	oxytocin; targeted mutation 1, W Scott Young III
MGI ID:	MGI:1857234
Synonyms:	OT-, OTKO -
Gene:	Oxt  Location: Chr2:130418093-130418974 bp, + strand  Genetic Position: Chr2, 63.24 cM
Alliance:	Oxttm1Wsy page

Germline Transmission:	Earliest citation of germline transmission: J:36926
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted using neomycin resistance cassette. The vector replaced sequences encoding the last two exons. Hybridization histochemistry and immunocytochemistry were used to demonstrate the lack of transcript and protein in homozygous mutant animals. (J:36926)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Oxt Mutation:	20 strains or lines available

Original:	J:36926 Young WS 3rd, et al., Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition. J Neuroendocrinol. 1996 Nov;8(11):847-53
All:	34 reference(s)