Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Ncam1tm1Cgn
Name:	neural cell adhesion molecule 1; targeted mutation 1, University of Cologne
MGI ID:	MGI:1857222
Synonyms:	Ncam-, N-CAM-, NCAM-, N-CAM-1-
Gene:	Ncam1  Location: Chr9:49413436-49710225 bp, - strand  Genetic Position: Chr9, 26.83 cM
Alliance:	Ncam1tm1Cgn page

Germline Transmission:	Earliest citation of germline transmission: J:16590
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced most of exons 3 and 4 and the intervening intron. Ribonuclease protection assays did not detect wild-type or read-through transcripts or alternative or cryptic splicing in brain tissue from homozygous mutant mice. Western blot analysis of brain tissue using a monoclonal antibody or a polyclonal rabbit serum did not detect protein in homozygous mutant mice. Similarly, immunostaining did not detect protein in mutant olfactory bulb. (J:16590)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	8 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

List all tumor models in MMHCdb carrying Ncam1tm1Cgn

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ncam1 Mutation:	65 strains or lines available

Original:	J:16590 Cremer H, et al., Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning. Nature. 1994 Feb 3;367(6462):455-9
All:	85 reference(s)