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Galns Gene Detail
Summary
  • Symbol
    Galns
  • Name
    galactosamine (N-acetyl)-6-sulfatase
  • Synonyms
    N-acetylgalactosamine-6-sulfate sulfatase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355303
    NCBI Gene: 50917
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:123304981-123338202 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 71.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    469 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355303
 protein coding gene Chr8:123304976-123338226 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034232
 protein coding gene Chr8:126130949-126172151 (-)
A/J MGP_AJ_G0034212
 protein coding gene Chr8:120906401-120941463 (-)
AKR/J MGP_AKRJ_G0034139
 protein coding gene Chr8:124428991-124468094 (-)
BALB/cJ MGP_BALBcJ_G0034206
 protein coding gene Chr8:121106928-121140999 (-)
C3H/HeJ MGP_C3HHeJ_G0033917
 protein coding gene Chr8:125129282-125169615 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034726
 protein coding gene Chr8:130343944-130379652 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031668
 protein coding gene Chr8:113740857-113773168 (-)
CAST/EiJ MGP_CASTEiJ_G0033244
 protein coding gene Chr8:125213569-125248361 (-)
CBA/J MGP_CBAJ_G0033890
 protein coding gene Chr8:135125635-135168327 (-)
DBA/2J MGP_DBA2J_G0034046
 protein coding gene Chr8:120095467-120130167 (-)
FVB/NJ MGP_FVBNJ_G0033989
 protein coding gene Chr8:119241702-119276644 (-)
LP/J MGP_LPJ_G0034135
 protein coding gene Chr8:126253805-126296509 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034036
 protein coding gene Chr8:137294008-137332028 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034744
 protein coding gene Chr8:124613350-124650155 (-)
PWK/PhJ MGP_PWKPhJ_G0032946
 protein coding gene Chr8:119919831-119953282 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032786
 protein coding gene Chr8:123343398-123378744 (-)
WSB/EiJ MGP_WSBEiJ_G0033360
 protein coding gene Chr8:125368147-125405064 (-)



Homology
more
  • Human Ortholog
    GALNS, galactosamine (N-acetyl)-6-sulfatase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GALNS, galactosamine (N-acetyl)-6-sulfatase
  • Synonyms
    GalN6S, GALNAC6S, GAS, MPS4A
  • Links
    NCBI Gene ID: 2588
    neXtProt AC: NX_P34059
    UniProt: P34059

  • Chr Location
    16q24.3; chr16:88813734-88856970 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Galns mouse models; 1 with human GALNS associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are viable, fertile, and healthy in spite of lysosmal storage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    810
  • Tissues
    102
  • cDNA Data
    52
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015027 Ensembl Gene Model | MGI Sequence Detail 33222 C57BL/6J ±  kb
    transcript ENSMUST00000015171 Ensembl | MGI Sequence Detail 2557 Not Applicable  
    polypeptide ENSMUSP00000015171 Ensembl | MGI Sequence Detail 520 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 52

      Microarray probesets 3
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:60994 Montano AM, et al., The mouse N-acetylgalactosamine-6-sulfate sulfatase (Galns) gene: cDNA isolation, genomic characterization, chromosomal assignment and analysis of the 5'-flanking region. Biochim Biophys Acta. 2000 Mar 17;1500(3):323-34
    • Latest
      J:346624 Alvarez JV, et al., Morquio A Syndrome: Identification of Differential Patterns of Molecular Pathway Interactions in Bone Lesions. Int J Mol Sci. 2024 Mar 12;25(6)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory