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Hmgn5 Gene Detail
Summary
  • Symbol
    Hmgn5
  • Name
    high-mobility group nucleosome binding domain 5
  • Synonyms
    GARP45, NBP-45, Nsbp1, nucleosome binding protein 45
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355295
    NCBI Gene: 50887
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:108048143-108056986 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 47.92 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    43 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355295
 protein coding gene ChrX:108048140-108057010 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036021
 protein coding gene ChrX:105854172-105862489 (-)
A/J MGP_AJ_G0036000
 protein coding gene ChrX:105712004-105721368 (-)
AKR/J MGP_AKRJ_G0035919
 protein coding gene ChrX:109004268-109013736 (-)
BALB/cJ MGP_BALBcJ_G0035991
 protein coding gene ChrX:104397408-104406171 (-)
C3H/HeJ MGP_C3HHeJ_G0035697
 protein coding gene ChrX:106305502-106314341 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036517
 protein coding gene ChrX:108901899-108910733 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033345
 protein coding gene ChrX:102778045-102786488 (-)
CAST/EiJ MGP_CASTEiJ_G0034984
 protein coding gene ChrX:90348136-90356894 (-)
CBA/J MGP_CBAJ_G0035673
 protein coding gene ChrX:112316765-112328319 (-)
DBA/2J MGP_DBA2J_G0035827
 protein coding gene ChrX:104873663-104882531 (-)
FVB/NJ MGP_FVBNJ_G0035767
 protein coding gene ChrX:104263829-104273749 (-)
LP/J MGP_LPJ_G0035919
 protein coding gene ChrX:106862453-106870756 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035798
 protein coding gene ChrX:117328884-117344471 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036544
 protein coding gene ChrX:105404767-105413611 (-)
PWK/PhJ MGP_PWKPhJ_G0034680
 protein coding gene ChrX:87882046-87891106 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034509
 protein coding gene ChrX:91191728-91204612 (-)
WSB/EiJ MGP_WSBEiJ_G0035122
 protein coding gene ChrX:104145606-104154351 (-)



Homology
more
  • Human Ortholog
    HMGN5, high mobility group nucleosome binding domain 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMGN5, high mobility group nucleosome binding domain 5
  • Synonyms
    NBP-45, NSBP1
  • Links
    NCBI Gene ID: 79366
    neXtProt AC: NX_P82970
    UniProt: P82970

  • Chr Location
    Xq21.1; chrX:81113699-81201913 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased prepulse inhibition, abnormal erythrocyte cell number, abnormal glucose tolerance, decreased granulocyte, increased CD8+ T cells, increased IgA, decreased IgE and abnormal respiration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    770
  • Tissues
    52
  • cDNA Data
    47
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 50887 NCBI Gene Model | MGI Sequence Detail 8844 C57BL/6J ±  kb
    transcript NM_016710 RefSeq | MGI Sequence Detail 1911 C57BL/6  
    polypeptide Q9JL35 UniProt | EBI | MGI Sequence Detail 406 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 48
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:60860 Shirakawa H, et al., NBP-45, a novel nucleosomal binding protein with a tissue-specific and developmentally regulated expression. J Biol Chem. 2000 Mar 3;275(9):6368-74
    • Latest
      J:219709 Furusawa T, et al., Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness. Nat Commun. 2015;6:6138
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory