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Kdm2a Gene Detail
Summary
  • Symbol
    Kdm2a
  • Name
    lysine (K)-specific demethylase 2A
  • Synonyms
    5530401A10Rik, Cxxc8, Fbl7, Fbxl11, Gm4560, Jhdm1a, lalina
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354736
    NCBI Gene: 225876
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4366172-4448749 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.01 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    307 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354736
 protein coding gene Chr19:4364447-4448749 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024662
 protein coding gene Chr19:1176123-1263719 (-)
A/J MGP_AJ_G0024628
 protein coding gene Chr19:1119570-1202978 (-)
AKR/J MGP_AKRJ_G0024601
 protein coding gene Chr19:1146624-1239101 (-)
BALB/cJ MGP_BALBcJ_G0024628
 protein coding gene Chr19:1109228-1193656 (-)
C3H/HeJ MGP_C3HHeJ_G0024396
 protein coding gene Chr19:1152176-1238492 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025076
 protein coding gene Chr19:1218090-1315057 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022505
 protein coding gene Chr19:1056558-1141719 (-)
CAST/EiJ MGP_CASTEiJ_G0023868
 protein coding gene Chr19:1159500-1250185 (-)
CBA/J MGP_CBAJ_G0024367
 protein coding gene Chr19:1282536-1378524 (-)
DBA/2J MGP_DBA2J_G0024495
 protein coding gene Chr19:1079351-1163533 (-)
FVB/NJ MGP_FVBNJ_G0024462
 protein coding gene Chr19:1093495-1188121 (-)
LP/J MGP_LPJ_G0024581
 protein coding gene Chr19:1183908-1276587 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024492
 protein coding gene Chr19:1214229-1304539 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025123
 protein coding gene Chr19:1152459-1240297 (-)
PWK/PhJ MGP_PWKPhJ_G0023614
 protein coding gene Chr19:1134061-1220438 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023419
 protein coding gene Chr19:1131491-1226677 (-)
WSB/EiJ MGP_WSBEiJ_G0023930
 protein coding gene Chr19:1142285-1233678 (-)



Homology
more
  • Human Ortholog
    KDM2A, lysine demethylase 2A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KDM2A, lysine demethylase 2A
  • Synonyms
    CXXC8, FBL11, FBL7, FBXL11, JHDM1A, LILINA
  • Links
    NCBI Gene ID: 22992
    neXtProt AC: NX_Q9Y2K7
    UniProt: Q9Y2K7

  • Chr Location
    11q13.2; chr11:67119263-67258082 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KDM2A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show embryonic lethality, severe growth retardation, reduced neuron proliferation, increased neuron apoptosis, impaired neuron differentiation, small hearts, abnormal cardiac looping and, in some cases, incomplete embryonic turning and neural tube closure defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    10
  • cDNA Data
    21
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 225876 NCBI Gene Model | MGI Sequence Detail 82578 C57BL/6J ±  kb
    transcript NM_001001984 RefSeq | MGI Sequence Detail 7268 C57BL/6  
    polypeptide P59997 UniProt | EBI | MGI Sequence Detail 1161 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 21
      Primer pair 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1918681, MGI:2147454, MGI:2147738, MGI:3782744
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 7
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:58149 Winston JT, et al., A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21;9(20):1180-2
    • Latest
      J:337791 Iwagawa T, et al., The histone H3K36 demethylase Fbxl11 plays pivotal roles in the development of retinal late-born cell types. Genes Cells. 2023 Jul;28(7):482-495
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory