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Clic4 Gene Detail
Summary
  • Symbol
    Clic4
  • Name
    chloride intracellular channel 4
  • Synonyms
    D0Jmb3, mc3s5, mtCLIC
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352754
    NCBI Gene: 29876
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr4:134941280-135000071 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 67.19 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    708 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352754
 protein coding gene Chr4:134941280-135000125 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028940
 protein coding gene Chr4:137631001-137692955 (-)
A/J MGP_AJ_G0028899
 protein coding gene Chr4:131822965-131885265 (-)
AKR/J MGP_AKRJ_G0028851
 protein coding gene Chr4:135611658-135680227 (-)
BALB/cJ MGP_BALBcJ_G0028923
 protein coding gene Chr4:132477960-132537549 (-)
C3H/HeJ MGP_C3HHeJ_G0028637
 protein coding gene Chr4:135875672-135939077 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029364
 protein coding gene Chr4:142558561-142626134 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026635
 protein coding gene Chr4:124876182-124936910 (-)
CAST/EiJ MGP_CASTEiJ_G0028069
 protein coding gene Chr4:133997539-134068034 (-)
CBA/J MGP_CBAJ_G0028602
 protein coding gene Chr4:146352036-146507190 (-)
DBA/2J MGP_DBA2J_G0028751
 protein coding gene Chr4:132244232-132303451 (-)
FVB/NJ MGP_FVBNJ_G0028718
 protein coding gene Chr4:131160249-131219194 (-)
LP/J MGP_LPJ_G0028850
 protein coding gene Chr4:137738779-137799574 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028744
 protein coding gene Chr4:150770670-150833728 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029402
 protein coding gene Chr4:136061982-136126831 (-)
PWK/PhJ MGP_PWKPhJ_G0027789
 protein coding gene Chr4:129007403-129070219 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027615
 protein coding gene Chr4:131892412-131952240 (-)
WSB/EiJ MGP_WSBEiJ_G0028147
 protein coding gene Chr4:136237419-136298569 (-)



Homology
more
  • Human Ortholog
    CLIC4, chloride intracellular channel 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLIC4, chloride intracellular channel 4
  • Synonyms
    CLIC4L, H1, huH1, MTCLIC, p64H1
  • Links
    NCBI Gene ID: 25932
    neXtProt AC: NX_Q9Y696
    UniProt: Q9Y696

  • Chr Location
    1p36.11; chr1:24745382-24844321 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 4 alleles in 5 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations may display decreased survival, body weight and female fertility, impaired angiogenesis, increased suscpetibility to Listeria infection, increased resistance to LPS treatment, skin erosions and/or delayed wound healing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    835
  • Tissues
    119
  • cDNA Data
    404
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 29876 NCBI Gene Model | MGI Sequence Detail 58792 C57BL/6J ±  kb
    transcript NM_013885 RefSeq | MGI Sequence Detail 4065 C57BL/6  
    polypeptide Q9QYB1 UniProt | EBI | MGI Sequence Detail 253 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000005577 chloride intracellular channel protein 4
      (term hierarchy)
    • InterPro Domains
      IPR036282 Glutathione S-transferase, C-terminal domain superfamily
      IPR010987 Glutathione S-transferase, C-terminal-like
      IPR004045 Glutathione S-transferase, N-terminal
      IPR040079 Glutathione transferase family
      IPR002946 Intracellular chloride channel
      IPR036249 Thioredoxin-like superfamily
    Molecular
    Reagents
    less
    • All nucleic 406
      cDNA 405
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1206574
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 3
      Gene Ontology 14
      Phenotypes 28
    • Earliest
      J:25193 Gordon HM, et al., Tumor necrosis factor induces genes involved in inflammation, cellular and tissue repair, and metabolism in murine fibroblasts. J Immunol. 1992 Jun 15;148(12):4021-7
    • Latest
      J:339451 Kleinjan ML, et al., CLIC4 Regulates Endothelial Barrier Control by Mediating PAR1 Signaling via RhoA. Arterioscler Thromb Vasc Biol. 2023 Aug;43(8):1441-1454
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory