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Nkx6-2 Gene Detail
Summary
  • Symbol
    Nkx6-2
  • Name
    NK6 homeobox 2
  • Synonyms
    Gtx, Nkx6.2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352738
    NCBI Gene: 14912
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:139159292-139162713 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 84.57 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    14 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352738
 protein coding gene Chr7:139159292-139162726 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033151
 protein coding gene Chr7:144609782-144613202 (-)
A/J MGP_AJ_G0033133
 protein coding gene Chr7:140525289-140528709 (-)
AKR/J MGP_AKRJ_G0033065
 protein coding gene Chr7:144330754-144334170 (-)
BALB/cJ MGP_BALBcJ_G0033134
 protein coding gene Chr7:140267028-140270448 (-)
C3H/HeJ MGP_C3HHeJ_G0032848
 protein coding gene Chr7:144142100-144145520 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033645
 protein coding gene Chr7:149946620-149950041 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030618
 protein coding gene Chr7:141656551-141659989 (-)
CAST/EiJ MGP_CASTEiJ_G0032178
 protein coding gene Chr7:136433008-136436434 (-)
CBA/J MGP_CBAJ_G0032821
 protein coding gene Chr7:155007243-155010663 (-)
DBA/2J MGP_DBA2J_G0032973
 protein coding gene Chr7:138481025-138484445 (-)
FVB/NJ MGP_FVBNJ_G0032926
 protein coding gene Chr7:138365190-138368610 (-)
LP/J MGP_LPJ_G0033067
 protein coding gene Chr7:146159442-146162862 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032958
 protein coding gene Chr7:155698323-155701743 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033665
 protein coding gene Chr7:143321403-143324824 (-)
PWK/PhJ MGP_PWKPhJ_G0031884
 protein coding gene Chr7:131652466-131655882 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031729
 protein coding gene Chr7:130158244-130161679 (-)
WSB/EiJ MGP_WSBEiJ_G0032289
 protein coding gene Chr7:144238295-144241715 (-)



Homology
more
  • Human Ortholog
    NKX6-2, NK6 homeobox 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NKX6-2, NK6 homeobox 2
  • Synonyms
    GTX, NKX6.2, NKX6B, SPAX8
  • Links
    NCBI Gene ID: 84504
    neXtProt AC: NX_Q9C056
    UniProt: Q9C056

  • Chr Location
    10q26.3; chr10:132783179-132786147 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NKX6-2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 4 alleles in 4 genetic backgrounds
    7 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired coordination at 6 weeks of age and axon degeneration in the optic nerve at 7 months of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    906
  • Tissues
    112
  • cDNA Data
    9
  • Literature Summary
    73
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041309 Ensembl Gene Model | MGI Sequence Detail 3422 C57BL/6J ±  kb
    transcript ENSMUST00000097974 Ensembl | MGI Sequence Detail 1907 Not Applicable  
    polypeptide ENSMUSP00000095588 Ensembl | MGI Sequence Detail 277 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 2
      cDNA 10
      Primer pair 2
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10330, MGI:95870
    References
    more
    • Summaries
      All 114
      Developmental Gene Expression 73
      Gene Ontology 9
      Phenotypes 29
    • Earliest
      J:4385 Komuro I, et al., Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter. EMBO J. 1993 Apr;12(4):1387-401
    • Latest
      J:342341 Bechelli L, et al., Selective dopamine D2 receptor deletion from Nkx6.2 expressing cells causes impaired cognitive, motivation and anxiety phenotypes in mice. Sci Rep. 2023 Nov 9;13(1):19473
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory