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Nr2c2 Gene Detail
Summary
  • Symbol
    Nr2c2
  • Name
    nuclear receptor subfamily 2, group C, member 2
  • Synonyms
    TAK1, Tr4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352466
    NCBI Gene: 22026
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:92068426-92150039 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 41.03 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    305 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352466
 protein coding gene Chr6:92068371-92151275 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031055
 protein coding gene Chr6:93723163-93806817 (+)
A/J MGP_AJ_G0031024
 protein coding gene Chr6:90154333-90238910 (+)
AKR/J MGP_AKRJ_G0030955
 protein coding gene Chr6:92649833-92732834 (+)
BALB/cJ MGP_BALBcJ_G0031035
 protein coding gene Chr6:90117391-90199812 (+)
C3H/HeJ MGP_C3HHeJ_G0030673
 protein coding gene Chr6:91697840-91780995 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031494
 protein coding gene Chr6:96142966-96221847 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028661
 protein coding gene Chr6:88140582-88212206 (+)
CAST/EiJ MGP_CASTEiJ_G0030142
 protein coding gene Chr6:92782274-92864178 (+)
CBA/J MGP_CBAJ_G0030721
 protein coding gene Chr6:99719319-99801583 (+)
DBA/2J MGP_DBA2J_G0030874
 protein coding gene Chr6:89330768-89413734 (+)
FVB/NJ MGP_FVBNJ_G0030828
 protein coding gene Chr6:88546222-88629876 (+)
LP/J MGP_LPJ_G0030954
 protein coding gene Chr6:93676313-93758141 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030862
 protein coding gene Chr6:103755758-103842277 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031521
 protein coding gene Chr6:92501251-92585239 (+)
PWK/PhJ MGP_PWKPhJ_G0029858
 protein coding gene Chr6:88291185-88373070 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029687
 protein coding gene Chr6:91411044-91496223 (+)
WSB/EiJ MGP_WSBEiJ_G0030226
 protein coding gene Chr6:92973906-93054965 (+)



Homology
more
  • Human Ortholog
    NR2C2, nuclear receptor subfamily 2 group C member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NR2C2, nuclear receptor subfamily 2 group C member 2
  • Synonyms
    TAK1, TR4
  • Links
    NCBI Gene ID: 7182
    neXtProt AC: NX_P49116
    UniProt: P49116

  • Chr Location
    3p25.1; chr3:14947583-15053600 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    77 phenotypes from 4 alleles in 6 genetic backgrounds
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show smaller body size, subfertility, defects in spermatogenesis and ovarian folliculogenesis, irregular estrous cycles, few/no preovulatory follicles and corpora lutea, increased granulosa cell apoptosis, and increased serum progesterone and estradiol levels after superovulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    944
  • Tissues
    169
  • cDNA Data
    17
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22026 NCBI Gene Model | MGI Sequence Detail 81614 C57BL/6J ±  kb
    transcript NM_001410485 RefSeq | MGI Sequence Detail 7846 C57BL/6  
    polypeptide P49117 UniProt | EBI | MGI Sequence Detail 596 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000011400 nuclear receptor subfamily 2 group C member 2
      (term hierarchy)
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR033544 Nuclear receptor subfamily 0 group B member 1/2
      IPR048245 Nuclear receptor subfamily 2 group C member 1/2-like, DNA-binding domain
      IPR048246 Nuclear receptor subfamily 2 group C member 1/2-like, ligand binding domain
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 19
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-19627, MGI:102723
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 12
      Gene Ontology 11
      Phenotypes 42
    • Earliest
      J:22291 Hirose T, et al., TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily. Mol Endocrinol. 1994 Dec;8(12):1667-80
    • Latest
      J:342344 Ma M, et al., TAK1 is an essential kinase for STING trafficking. Mol Cell. 2023 Nov 2;83(21):3885-3903.e5
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory