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Mmel1 Gene Detail
Summary
  • Symbol
    Mmel1
  • Name
    membrane metallo-endopeptidase-like 1
  • Synonyms
    Mell1, Nep2, NEPLP alpha, NEPLP beta, NEPLP gamma, Nl1, SEP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351603
    NCBI Gene: 27390
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:154954042-154979985 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 85.54 cM, cytoband E2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    276 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351603
 protein coding gene Chr4:154954042-154979987 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029200
 protein coding gene Chr4:159150790-159177301 (+)
A/J MGP_AJ_G0029165
 protein coding gene Chr4:152473149-152498579 (+)
AKR/J MGP_AKRJ_G0029113
 protein coding gene Chr4:156628893-156655031 (+)
BALB/cJ MGP_BALBcJ_G0029181
 protein coding gene Chr4:152939736-152966879 (+)
C3H/HeJ MGP_C3HHeJ_G0028902
 protein coding gene Chr4:157167487-157192236 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029630
 protein coding gene Chr4:164834416-164868545 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026876
 protein coding gene Chr4:144774049-144800653 (+)
CAST/EiJ MGP_CASTEiJ_G0028315
 protein coding gene Chr4:154590156-154619832 (+)
CBA/J MGP_CBAJ_G0028864
 protein coding gene Chr4:169775520-169806612 (+)
DBA/2J MGP_DBA2J_G0029013
 protein coding gene Chr4:152498353-152524236 (+)
FVB/NJ MGP_FVBNJ_G0028977
 protein coding gene Chr4:151714765-151741715 (+)
LP/J MGP_LPJ_G0029103
 protein coding gene Chr4:159071181-159100589 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029004
 protein coding gene Chr4:172661206-172689355 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029662
 protein coding gene Chr4:157217009-157246089 (+)
PWK/PhJ MGP_PWKPhJ_G0028035
 protein coding gene Chr4:148616789-148645591 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027869
 protein coding gene Chr4:151504061-151528618 (+)
WSB/EiJ MGP_WSBEiJ_G0028395
 protein coding gene Chr4:157385576-157411877 (+)



Homology
more
  • Human Ortholog
    MMEL1, membrane metalloendopeptidase like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MMEL1, membrane metalloendopeptidase like 1
  • Synonyms
    MMEL2, NEP2, NEPII, NL1, NL2, SEP
  • Links
    NCBI Gene ID: 79258
    neXtProt AC: NX_Q495T6
    UniProt: Q495T6

  • Chr Location
    1p36.32; chr1:2590639-2633016 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display impaired male fertility. Female fertility is not affected.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000058183 Ensembl Gene Model | MGI Sequence Detail 25944 C57BL/6J ±  kb
    transcript ENSMUST00000079269 Ensembl | MGI Sequence Detail 2934 Not Applicable  
    polypeptide ENSMUSP00000078252 Ensembl | MGI Sequence Detail 768 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4

      Microarray probesets 3
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:58258 Ikeda K, et al., Molecular identification and characterization of novel membrane-bound metalloprotease, the soluble secreted form of which hydrolyzes a variety of vasoactive peptides. J Biol Chem. 1999 Nov 5;274(45):32469-77
    • Latest
      J:284960 Karoor V, et al., Sustained Activation of Rho GTPases Promotes a Synthetic Pulmonary Artery Smooth Muscle Cell Phenotype in Neprilysin Null Mice. Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):154-163
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory