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Nubp2 Gene Detail
Summary
  • Symbol
    Nubp2
  • Name
    nucleotide binding protein 2
  • Synonyms
    D17Wsu11e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347072
    NCBI Gene: 26426
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:25101585-25105323 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.53 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347072
 protein coding gene Chr17:25101585-25105423 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023327
 protein coding gene Chr17:23908096-23911823 (-)
A/J MGP_AJ_G0023287
 protein coding gene Chr17:23244830-23248575 (-)
AKR/J MGP_AKRJ_G0023254
 protein coding gene Chr17:23333384-23337111 (-)
BALB/cJ MGP_BALBcJ_G0023292
 protein coding gene Chr17:23445350-23449077 (-)
C3H/HeJ MGP_C3HHeJ_G0023052
 protein coding gene Chr17:23697982-23701709 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023735
 protein coding gene Chr17:24970921-24974660 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021210
 protein coding gene Chr17:20705116-20708795 (-)
CAST/EiJ MGP_CASTEiJ_G0022554
 protein coding gene Chr17:23553195-23556945 (-)
CBA/J MGP_CBAJ_G0023028
 protein coding gene Chr17:25812272-25815999 (-)
DBA/2J MGP_DBA2J_G0023157
 protein coding gene Chr17:22837493-22841238 (-)
FVB/NJ MGP_FVBNJ_G0023127
 protein coding gene Chr17:22558046-22561773 (-)
LP/J MGP_LPJ_G0023234
 protein coding gene Chr17:24213359-24217086 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023146
 protein coding gene Chr17:25504695-25508440 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023773
 protein coding gene Chr17:23617834-23621579 (-)
PWK/PhJ MGP_PWKPhJ_G0022303
 protein coding gene Chr17:21592874-21596615 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022121
 protein coding gene Chr17:21682122-21685851 (-)
WSB/EiJ MGP_WSBEiJ_G0022617
 protein coding gene Chr17:23690480-23694215 (-)



Homology
more
  • Human Ortholog
    NUBP2, NUBP iron-sulfur cluster assembly factor 2, cytosolic
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NUBP2, NUBP iron-sulfur cluster assembly factor 2, cytosolic
  • Synonyms
    CFD1, CIAO6, NBP 2, NUBP1
  • Links
    NCBI Gene ID: 10101
    neXtProt AC: NX_Q9Y5Y2
    UniProt: Q9Y5Y2

  • Chr Location
    16p13.3; chr16:1782932-1789186 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    14
  • cDNA Data
    81
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039183 Ensembl Gene Model | MGI Sequence Detail 3739 C57BL/6J ±  kb
    transcript ENSMUST00000044252 Ensembl | MGI Sequence Detail 1427 Not Applicable  
    polypeptide ENSMUSP00000049319 Ensembl | MGI Sequence Detail 275 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000011477 cytosolic Fe-S cluster assembly factor NUBP2
      (term hierarchy)
    • InterPro Domains
      IPR028600 Cytosolic Fe-S cluster assembly factor NUBP2/Cfd1, eukaryotes
      IPR033756 Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35
      IPR000808 Iron-sulfur cluster carrier protein-like, conserved site
      IPR019591 Mrp/NBP35 ATP-binding protein
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 82
      cDNA 81
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-33980, MGI:106288
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:284772 DiStasio A, et al., Nubp2 is required for cranial neural crest survival in the mouse. Dev Biol. 2020 Feb 15;458(2):189-199
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory