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Decr2 Gene Detail
Summary
  • Symbol
    Decr2
  • Name
    2-4-dienoyl-Coenzyme A reductase 2, peroxisomal
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347059
    NCBI Gene: 26378
  • Alliance
  • Transcription Start Sites
    8 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr17:26300182-26309096 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 13.06 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    132 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347059
protein coding gene Chr17:26300182-26309311 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023388
protein coding gene Chr17:25209348-25219674 (-)
A/J MGP_AJ_G0023347
protein coding gene Chr17:24468521-24477655 (-)
AKR/J MGP_AKRJ_G0023313
protein coding gene Chr17:24575543-24586137 (-)
BALB/cJ MGP_BALBcJ_G0023352
protein coding gene Chr17:24690243-24700147 (-)
C3H/HeJ MGP_C3HHeJ_G0023112
protein coding gene Chr17:24966445-24975968 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023794
protein coding gene Chr17:26275367-26284769 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021270
protein coding gene Chr17:21919595-21929720 (-)
CAST/EiJ MGP_CASTEiJ_G0022614
protein coding gene Chr17:24860761-24871919 (-)
CBA/J MGP_CBAJ_G0023087
protein coding gene Chr17:27203537-27214269 (-)
DBA/2J MGP_DBA2J_G0023217
protein coding gene Chr17:24062972-24072149 (-)
FVB/NJ MGP_FVBNJ_G0023187
protein coding gene Chr17:23819866-23829611 (-)
LP/J MGP_LPJ_G0023294
protein coding gene Chr17:25496372-25508220 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023206
protein coding gene Chr17:26772992-26784961 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023834
protein coding gene Chr17:24907080-24918365 (-)
PWK/PhJ MGP_PWKPhJ_G0022363
protein coding gene Chr17:22832898-22841915 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022181
protein coding gene Chr17:22984160-22996779 (-)
WSB/EiJ MGP_WSBEiJ_G0022677
protein coding gene Chr17:24948550-24958326 (-)



Homology
more
  • Human Ortholog
    DECR2, 2,4-dienoyl-CoA reductase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DECR2, 2,4-dienoyl-CoA reductase 2
  • Synonyms
    PDCR, SDR17C1
  • Links
    NCBI Gene ID: 26063
    neXtProt AC: NX_Q9NUI1
    UniProt: Q9NUI1

  • Chr Location
    16p13.3; chr16:401858-412487 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26378 NCBI Gene Model | MGI Sequence Detail 8915 C57BL/6J ±  kb
    transcript NM_001411311 RefSeq | MGI Sequence Detail 2017 ZRU/MplStud  
    polypeptide Q9WV68 UniProt | EBI | MGI Sequence Detail 292 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000006374 peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
    • EC
    • InterPro Domains
      IPR036291 NAD(P)-binding domain superfamily
      IPR045017 Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
      IPR002347 Short-chain dehydrogenase/reductase SDR
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 48
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 33
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:57230 Geisbrecht BV, et al., The mouse gene PDCR encodes a peroxisomal delta(2), delta(4)-dienoyl-CoA reductase. J Biol Chem. 1999 Sep 3;274(36):25814-20
    • Latest
      J:194116 Flachs P, et al., Interallelic and intergenic incompatibilities of the Prdm9 (Hst1) gene in mouse hybrid sterility. PLoS Genet. 2012;8(11):e1003044

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory