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Bves Gene Detail
Summary
  • Symbol
    Bves
  • Name
    blood vessel epicardial substance
  • Synonyms
    Popdc1, popeye 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346013
    NCBI Gene: 23828
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:45211868-45248575 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 23.47 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    160 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346013
 protein coding gene Chr10:45211783-45248580 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017208
 protein coding gene Chr10:44234725-44271312 (+)
A/J MGP_AJ_G0017184
 protein coding gene Chr10:42983211-43018191 (+)
AKR/J MGP_AKRJ_G0017143
 protein coding gene Chr10:43667433-43708049 (+)
BALB/cJ MGP_BALBcJ_G0017145
 protein coding gene Chr10:43032947-43074100 (+)
C3H/HeJ MGP_C3HHeJ_G0016969
 protein coding gene Chr10:43978178-44015409 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017603
 protein coding gene Chr10:45581694-45620661 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015298
 protein coding gene Chr10:40873709-40906248 (+)
CAST/EiJ MGP_CASTEiJ_G0016543
 protein coding gene Chr10:44252530-44287233 (+)
CBA/J MGP_CBAJ_G0016940
 protein coding gene Chr10:47613688-47654970 (+)
DBA/2J MGP_DBA2J_G0017045
 protein coding gene Chr10:42396298-42430782 (+)
FVB/NJ MGP_FVBNJ_G0017039
 protein coding gene Chr10:41900028-41933697 (+)
LP/J MGP_LPJ_G0017120
 protein coding gene Chr10:44263780-44298620 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017068
 protein coding gene Chr10:48271937-48309205 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017639
 protein coding gene Chr10:43666325-43704928 (+)
PWK/PhJ MGP_PWKPhJ_G0016322
 protein coding gene Chr10:42375349-42411617 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016107
 protein coding gene Chr10:43465735-43509110 (+)
WSB/EiJ MGP_WSBEiJ_G0016606
 protein coding gene Chr10:43908709-43946154 (+)



Homology
more
  • Human Ortholog
    BVES, blood vessel epicardial substance
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BVES, blood vessel epicardial substance
  • Synonyms
    CARICK, HBVES, LGMD2X, LGMDR25, POP1, POPDC1
  • Links
    NCBI Gene ID: 11149
    neXtProt AC: NX_Q8NE79
    UniProt: Q8NE79

  • Chr Location
    6q21; chr6:105096822-105137157 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human BVES associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in delayed muscle regeneration following induced injury. Mice homozygous for a knock-out allele exhibit sinus brachycardia in response to physical or mental stress and catecholamines with a compact sinoatrial node.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    859
  • Tissues
    68
  • cDNA Data
    22
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000071317 Ensembl Gene Model | MGI Sequence Detail 36708 C57BL/6J ±  kb
    transcript ENSMUST00000095715 Ensembl | MGI Sequence Detail 4368 Not Applicable  
    polypeptide ENSMUSP00000093382 Ensembl | MGI Sequence Detail 358 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 22
      Primer pair 2
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 9
      Gene Ontology 11
      Phenotypes 21
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:334940 Li H, et al., Defective BVES-mediated feedback control of cAMP in muscular dystrophy. Nat Commun. 2023 Mar 30;14(1):1785
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory