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Slc34a1 Gene Detail
Summary
  • Symbol
    Slc34a1
  • Name
    solute carrier family 34 (sodium phosphate), member 1
  • Synonyms
    Na/Pi cotransporter, NaPi-IIa, Npt2, renal Na+/Pi transporter, Slc17a2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345284
    NCBI Gene: 20505
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:55547435-55562508 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 29.81 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    172 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345284
 protein coding gene Chr13:55546000-55563405 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020594
 protein coding gene Chr13:54879274-54894295 (+)
A/J MGP_AJ_G0020548
 protein coding gene Chr13:52851385-52865158 (+)
AKR/J MGP_AKRJ_G0020526
 protein coding gene Chr13:54404415-54419448 (+)
BALB/cJ MGP_BALBcJ_G0020544
 protein coding gene Chr13:53078772-53092569 (+)
C3H/HeJ MGP_C3HHeJ_G0020343
 protein coding gene Chr13:54222251-54236024 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020978
 protein coding gene Chr13:56531635-56546674 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018560
 protein coding gene Chr13:50797460-50812808 (+)
CAST/EiJ MGP_CASTEiJ_G0019857
 protein coding gene Chr13:54321483-54336472 (+)
CBA/J MGP_CBAJ_G0020303
 protein coding gene Chr13:58701329-58715255 (+)
DBA/2J MGP_DBA2J_G0020426
 protein coding gene Chr13:52401775-52416837 (+)
FVB/NJ MGP_FVBNJ_G0020405
 protein coding gene Chr13:51870151-51885219 (+)
LP/J MGP_LPJ_G0020502
 protein coding gene Chr13:55134219-55150093 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020434
 protein coding gene Chr13:58170247-58185287 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021021
 protein coding gene Chr13:53995950-54010962 (+)
PWK/PhJ MGP_PWKPhJ_G0019613
 protein coding gene Chr13:52427629-52442893 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019440
 protein coding gene Chr13:52916355-52931322 (+)
WSB/EiJ MGP_WSBEiJ_G0019919
 protein coding gene Chr13:54352710-54367734 (+)



Homology
more
  • Human Ortholog
    SLC34A1, solute carrier family 34 member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC34A1, solute carrier family 34 member 1
  • Synonyms
    FRTS2, HCINF2, NAPI-3, NPHLOP1, NPT2, NPTIIa, SLC11, SLC17A2
  • Links
    NCBI Gene ID: 6569
    neXtProt AC: NX_Q06495
    UniProt: Q06495

  • Chr Location
    5q35.3; chr5:177379235-177398848 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Slc34a1 mouse models; 7 with human SLC34A1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 1 allele in 2 genetic backgrounds
    16 phenotypes from multigenic genotypes
    1 images
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit renal phosphate wasting, hyerpcalciuria, and skeletal abnormalities. Postnatal viability is reduced, putatively due to poor nutritional status.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    968
  • Tissues
    122
  • cDNA Data
    16
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20505 NCBI Gene Model | MGI Sequence Detail 15074 C57BL/6J ±  kb
    transcript NM_011392 RefSeq | MGI Sequence Detail 3081 ZRU/MplStud  
    polypeptide Q60825 UniProt | EBI | MGI Sequence Detail 637 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 10
      cDNA 16
      Primer pair 8
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16672, MGD-MRK-24044, MGI:103176
    References
    more
    • Summaries
      All 135
      Developmental Gene Expression 28
      Diseases 3
      Gene Ontology 13
      Phenotypes 61
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:343091 Stewart BZ, et al., Scribble scrambles parathyroid hormone receptor interactions to regulate phosphate and vitamin D homeostasis. Proc Natl Acad Sci U S A. 2023 Jun 6;120(23):e2220851120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory