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Lynx1 Gene Detail
Summary
  • Symbol
    Lynx1
  • Name
    Ly6/neurotoxin 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345180
    NCBI Gene: 23936
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:74619705-74624828 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 34.27 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    55 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345180
 protein coding gene Chr15:74619701-74624895 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021936
 protein coding gene Chr15:74531318-74537613 (-)
A/J MGP_AJ_G0021895
 protein coding gene Chr15:71871685-71876880 (-)
AKR/J MGP_AKRJ_G0021877
 protein coding gene Chr15:73712211-73717402 (-)
BALB/cJ MGP_BALBcJ_G0021902
 protein coding gene Chr15:71883162-71888356 (-)
C3H/HeJ MGP_C3HHeJ_G0021675
 protein coding gene Chr15:73866554-73871739 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022342
 protein coding gene Chr15:77347530-77352715 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019878
 protein coding gene Chr15:68283729-68288905 (-)
CAST/EiJ MGP_CASTEiJ_G0021194
 protein coding gene Chr15:74688532-74693697 (-)
CBA/J MGP_CBAJ_G0021641
 protein coding gene Chr15:79880237-79885425 (-)
DBA/2J MGP_DBA2J_G0021766
 protein coding gene Chr15:71470108-71475295 (-)
FVB/NJ MGP_FVBNJ_G0021748
 protein coding gene Chr15:70517862-70524024 (-)
LP/J MGP_LPJ_G0021838
 protein coding gene Chr15:74589673-74594863 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021771
 protein coding gene Chr15:85197239-85202434 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022363
 protein coding gene Chr15:74100858-74106047 (-)
PWK/PhJ MGP_PWKPhJ_G0020935
 protein coding gene Chr15:71577101-71582381 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020776
 protein coding gene Chr15:73989300-73994499 (-)
WSB/EiJ MGP_WSBEiJ_G0021246
 protein coding gene Chr15:74112816-74118011 (-)



Homology
more
  • Human Ortholog
    LYNX1, Ly6/neurotoxin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LYNX1, Ly6/neurotoxin 1
  • Links
    NCBI Gene ID: 66004
    neXtProt AC: NX_P0DP58
    UniProt: P0DP58

  • Chr Location
    8q24.3; chr8:142771197-142777872 (-)  GRCh38
  • Human Ortholog
    LYNX1-SLURP2, LYNX1-SLURP2 readthrough
  • Links
    NCBI Gene ID: 111188157
    neXtProt AC: NX_P0DP58

  • Chr Location
    chr8:142764334-142778224 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased sensitivity to nicotine, neurodegeneration, brain vacuoles amd improved cue-conditioned learning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    872
  • Tissues
    132
  • cDNA Data
    29
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23936 NCBI Gene Model | MGI Sequence Detail 5124 C57BL/6J ±  kb
    transcript NM_011838 RefSeq | MGI Sequence Detail 3952 C57BL/6  
    polypeptide P0DP60 UniProt | EBI | MGI Sequence Detail 116 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 30
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146067
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 8
      Phenotypes 37
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:323138 Doss SV, et al., Expression and Roles of Lynx1, a Modulator of Cholinergic Transmission, in Skeletal Muscles and Neuromuscular Junctions in Mice. Front Cell Dev Biol. 2022;10:838612
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory