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Mid2 Gene Detail
Summary
  • Symbol
    Mid2
  • Name
    midline 2
  • Synonyms
    FXY2, Trim1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344333
    NCBI Gene: 23947
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:139565348-139668464 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 61.35 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    430 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344333
 protein coding gene ChrX:139565326-139668464 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036136
 protein coding gene ChrX:138224560-138337594 (+)
A/J MGP_AJ_G0036114
 protein coding gene ChrX:137599140-137711208 (+)
AKR/J MGP_AKRJ_G0036039
 protein coding gene ChrX:142006530-142121196 (+)
BALB/cJ MGP_BALBcJ_G0036104
 protein coding gene ChrX:135907265-136015838 (+)
C3H/HeJ MGP_C3HHeJ_G0035813
 protein coding gene ChrX:138236245-138345212 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036629
 protein coding gene ChrX:142265639-142368306 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033453
 protein coding gene ChrX:129318486-129416959 (+)
CAST/EiJ MGP_CASTEiJ_G0035104
 protein coding gene ChrX:119057024-119159953 (+)
CBA/J MGP_CBAJ_G0035790
 protein coding gene ChrX:146641984-146756758 (+)
DBA/2J MGP_DBA2J_G0035947
 protein coding gene ChrX:136736699-136841482 (+)
FVB/NJ MGP_FVBNJ_G0035881
 protein coding gene ChrX:135971714-136076089 (+)
LP/J MGP_LPJ_G0036038
 protein coding gene ChrX:139175421-139274996 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035918
 protein coding gene ChrX:154157638-154282749 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036665
 protein coding gene ChrX:137528364-137638234 (+)
PWK/PhJ MGP_PWKPhJ_G0034797
 protein coding gene ChrX:115945919-116051098 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034623
 protein coding gene ChrX:119594748-119713319 (+)
WSB/EiJ MGP_WSBEiJ_G0035239
 protein coding gene ChrX:135846362-135953636 (+)



Homology
more
  • Human Ortholog
    MID2, midline 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MID2, midline 2
  • Synonyms
    FXY2, MRX101, RNF60, TRIM1, XLID101
  • Links
    NCBI Gene ID: 11043
    neXtProt AC: NX_Q9UJV3
    UniProt: Q9UJV3

  • Chr Location
    Xq22.3; chrX:107825735-107931637 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MID2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    944
  • Tissues
    188
  • cDNA Data
    20
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000266 Ensembl Gene Model | MGI Sequence Detail 103117 C57BL/6J ±  kb
    transcript ENSMUST00000112988 Ensembl | MGI Sequence Detail 2525 Not Applicable  
    polypeptide ENSMUSP00000108612 Ensembl | MGI Sequence Detail 715 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 20
      Primer pair 4
      Other 3

      Microarray probesets 5
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 6
    • Earliest
      J:56619 Buchner G, et al., MID2, a homologue of the Opitz syndrome gene MID1: similarities in subcellular localization and differences in expression during development. Hum Mol Genet. 1999 Aug;8(8):1397-407
    • Latest
      J:244447 Li B, et al., Mid1/Mid2 expression in craniofacial development and a literature review of X-linked opitz syndrome. Mol Genet Genomic Med. 2016 Jan;4(1):95-105
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory