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Wif1 Gene Detail
Summary
  • Symbol
    Wif1
  • Name
    Wnt inhibitory factor 1
  • Synonyms
    WIF-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344332
    NCBI Gene: 24117
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:120869909-120936547 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 68.98 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    320 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344332
 protein coding gene Chr10:120869865-120936555 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017779
 protein coding gene Chr10:124262781-124334962 (+)
A/J MGP_AJ_G0017754
 protein coding gene Chr10:119325690-119393077 (+)
AKR/J MGP_AKRJ_G0017717
 protein coding gene Chr10:122891490-122961394 (+)
BALB/cJ MGP_BALBcJ_G0017718
 protein coding gene Chr10:119717946-119787592 (+)
C3H/HeJ MGP_C3HHeJ_G0017542
 protein coding gene Chr10:123095936-123168584 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018173
 protein coding gene Chr10:128499099-128577012 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015853
 protein coding gene Chr10:113656112-113724976 (+)
CAST/EiJ MGP_CASTEiJ_G0017102
 protein coding gene Chr10:123445880-123517264 (+)
CBA/J MGP_CBAJ_G0017511
 protein coding gene Chr10:133735409-133811150 (+)
DBA/2J MGP_DBA2J_G0017617
 protein coding gene Chr10:118458124-118525830 (+)
FVB/NJ MGP_FVBNJ_G0017612
 protein coding gene Chr10:117445819-117513876 (+)
LP/J MGP_LPJ_G0017691
 protein coding gene Chr10:124802718-124874958 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017641
 protein coding gene Chr10:136283368-136357365 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018213
 protein coding gene Chr10:122910303-122982424 (+)
PWK/PhJ MGP_PWKPhJ_G0016887
 protein coding gene Chr10:118576199-118642063 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016678
 protein coding gene Chr10:121806525-121876196 (+)
WSB/EiJ MGP_WSBEiJ_G0017163
 protein coding gene Chr10:123145996-123216255 (+)



Homology
more
  • Human Ortholog
    WIF1, WNT inhibitory factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WIF1, WNT inhibitory factor 1
  • Synonyms
    WIF-1
  • Links
    NCBI Gene ID: 11197
    neXtProt AC: NX_Q9Y5W5
    UniProt: Q9Y5W5

  • Chr Location
    12q14.3; chr12:65050626-65121305 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human WIF1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    1 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and fertile but display increased susceptibility to spontaneous and induced osteosarcomas.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1507
  • Tissues
    644
  • cDNA Data
    37
  • Literature Summary
    71
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 24117 NCBI Gene Model | MGI Sequence Detail 66639 C57BL/6J ±  kb
transcript NM_011915 RefSeq | MGI Sequence Detail 2242 C57BL/6  
polypeptide Q9WUA1 UniProt | EBI | MGI Sequence Detail 379 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 51
    cDNA 37
    Primer pair 9
    Other 5

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143806
References
more
  • Summaries
    All 112
    Developmental Gene Expression 71
    Gene Ontology 4
    Phenotypes 16
  • Earliest
    J:54017 Hsieh JC, et al., A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature. 1999 Apr 1;398(6726):431-6
  • Latest
    J:338207 Moreau MX, et al., Repurposing of the multiciliation gene regulatory network in fate specification of Cajal-Retzius neurons. Dev Cell. 2023 Jun 7;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory