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Klk6 Gene Detail
Summary
  • Symbol
    Klk6
  • Name
    kallikrein related-peptidase 6
  • Synonyms
    Bssp, Klk29, neurosin, protease M, Prss18, Prss9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343166
    NCBI Gene: 19144
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:43473967-43481219 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.28 cM, cytoband B4-B5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    195 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343166
 protein coding gene Chr7:43473923-43481454 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032145
 protein coding gene Chr7:43874312-43883973 (+)
A/J MGP_AJ_G0032130
 protein coding gene Chr7:42954405-42963274 (+)
AKR/J MGP_AKRJ_G0032060
 protein coding gene Chr7:44340426-44349613 (+)
BALB/cJ MGP_BALBcJ_G0032135
 protein coding gene Chr7:43071672-43079421 (+)
C3H/HeJ MGP_C3HHeJ_G0031851
 protein coding gene Chr7:44848622-44857240 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032619
 protein coding gene Chr7:46081112-46091034 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029642
 protein coding gene Chr7:45088560-45095746 (+)
CAST/EiJ MGP_CASTEiJ_G0031181
 protein coding gene Chr7:36040136-36047608 (+)
CBA/J MGP_CBAJ_G0031820
 protein coding gene Chr7:47545478-47552999 (+)
DBA/2J MGP_DBA2J_G0031969
 protein coding gene Chr7:42761599-42768918 (+)
FVB/NJ MGP_FVBNJ_G0031930
 protein coding gene Chr7:42472865-42480246 (+)
LP/J MGP_LPJ_G0032048
 protein coding gene Chr7:44596022-44603537 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031966
 protein coding gene Chr7:46465187-46474777 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032639
 protein coding gene Chr7:43468819-43477206 (+)
PWK/PhJ MGP_PWKPhJ_G0030902
 protein coding gene Chr7:36212784-36220264 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030741
 protein coding gene Chr7:31497165-31507295 (+)
WSB/EiJ MGP_WSBEiJ_G0031295
 protein coding gene Chr7:44017111-44024636 (+)



Homology
more
  • Human Ortholog
    KLK6, kallikrein related peptidase 6
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLK6, kallikrein related peptidase 6
  • Synonyms
    Bssp, hK6, Klk7, PRSS18, PRSS9, SP59
  • Links
    NCBI Gene ID: 5653
    neXtProt AC: NX_Q92876
    UniProt: Q92876

  • Chr Location
    19q13.41; chr19:50958631-50969673 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human KLK6 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 1 genetic background
    9 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased mature oligodendrocytes in the developing spinal cord.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    772
  • Tissues
    30
  • cDNA Data
    13
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19144 NCBI Gene Model | MGI Sequence Detail 7253 C57BL/6J ±  kb
transcript NM_011177 RefSeq | MGI Sequence Detail 1165 ZRU/MplStud  
polypeptide NP_035307 RefSeq | MGI Sequence Detail 253 ZRU/MplStud  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
Molecular
Reagents
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  • All nucleic 18
    Genomic 2
    cDNA 13
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1347349, MGI:2142052
References
more
  • Summaries
    All 56
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:54930 Meier N, et al., A novel serine protease overexpressed in the hair follicles of nude mice. Biochem Biophys Res Commun. 1999 May 10;258(2):374-8
  • Latest
    J:334348 Hwang YS, et al., KLK6/PAR1 Axis Promotes Tumor Growth and Metastasis by Regulating Cross-Talk between Tumor Cells and Macrophages. Cells. 2022 Dec 16;11(24)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory