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Dctn6 Gene Detail
Summary
  • Symbol
    Dctn6
  • Name
    dynactin 6
  • Synonyms
    p27, WS-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343154
    NCBI Gene: 22428
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:34557574-34575866 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 20.90 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    242 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343154
 protein coding gene Chr8:34557574-34575950 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033530
 protein coding gene Chr8:32590570-32609949 (-)
A/J MGP_AJ_G0033510
 protein coding gene Chr8:31310232-31328406 (-)
AKR/J MGP_AKRJ_G0033434
 protein coding gene Chr8:32299147-32317641 (-)
BALB/cJ MGP_BALBcJ_G0033506
 protein coding gene Chr8:31430615-31448040 (-)
C3H/HeJ MGP_C3HHeJ_G0033218
 protein coding gene Chr8:32613927-32631645 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034022
 protein coding gene Chr8:33807496-33825849 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030971
 protein coding gene Chr8:28305211-28323859 (-)
CAST/EiJ MGP_CASTEiJ_G0032545
 protein coding gene Chr8:32079841-32096976 (-)
CBA/J MGP_CBAJ_G0033196
 protein coding gene Chr8:35132242-35149418 (-)
DBA/2J MGP_DBA2J_G0033349
 protein coding gene Chr8:31286509-31304901 (-)
FVB/NJ MGP_FVBNJ_G0033294
 protein coding gene Chr8:30942690-30960890 (-)
LP/J MGP_LPJ_G0033439
 protein coding gene Chr8:32544799-32563400 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033336
 protein coding gene Chr8:34654136-34678047 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034041
 protein coding gene Chr8:32370776-32389129 (-)
PWK/PhJ MGP_PWKPhJ_G0032257
 protein coding gene Chr8:30813921-30832549 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032088
 protein coding gene Chr8:31638946-31656938 (-)
WSB/EiJ MGP_WSBEiJ_G0032661
 protein coding gene Chr8:32542612-32560582 (-)



Homology
more
  • Human Ortholog
    DCTN6, dynactin subunit 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DCTN6, dynactin subunit 6
  • Synonyms
    p27, WS3, WS-3
  • Links
    NCBI Gene ID: 10671
    neXtProt AC: NX_O00399
    UniProt: O00399

  • Chr Location
    8p12; chr8:30156319-30183639 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show peri-implantation lethality. Cultured blastocysts fail to hatch from the zona pellucida with apparent cell death and form atypical outgrowth colonies with no trophectoderm, primitive endoderm or epiblast cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    13
  • cDNA Data
    91
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22428 NCBI Gene Model | MGI Sequence Detail 18293 C57BL/6J ±  kb
    transcript NM_001293759 RefSeq | MGI Sequence Detail 1365 C57BL/6NCrl  
    polypeptide Q9WUB4 UniProt | EBI | MGI Sequence Detail 190 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 92
      cDNA 91
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142720
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:54917 Murdock DG, et al., Up-regulation of nuclear and mitochondrial genes in the skeletal muscle of mice lacking the heart/muscle isoform of the adenine nucleotide translocator. J Biol Chem. 1999 May 14;274(20):14429-33
    • Latest
      J:315706 Sharoar MG, et al., Dynactin 6 deficiency enhances aging-associated dystrophic neurite formation in mouse brains. Neurobiol Aging. 2021 Nov;107:21-29
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory