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St6galnac4 Gene Detail
Summary
  • Symbol
    St6galnac4
  • Name
    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
  • Synonyms
    Siat7d, ST6GalNAc IV
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341894
    NCBI Gene: 20448
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:32477107-32489710 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 22.09 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    63 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341894
 protein coding gene Chr2:32477100-32489710 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025613
 protein coding gene Chr2:31063125-31075728 (+)
A/J MGP_AJ_G0025590
 protein coding gene Chr2:29734435-29748279 (+)
AKR/J MGP_AKRJ_G0025560
 protein coding gene Chr2:30801148-30813928 (+)
BALB/cJ MGP_BALBcJ_G0025587
 protein coding gene Chr2:29860206-29872809 (+)
C3H/HeJ MGP_C3HHeJ_G0025347
 protein coding gene Chr2:30689213-30701816 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026031
 protein coding gene Chr2:32005075-32017678 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023440
 protein coding gene Chr2:28454548-28467034 (+)
CAST/EiJ MGP_CASTEiJ_G0024809
 protein coding gene Chr2:30629868-30642445 (+)
CBA/J MGP_CBAJ_G0025325
 protein coding gene Chr2:33222691-33235294 (+)
DBA/2J MGP_DBA2J_G0025458
 protein coding gene Chr2:29502467-29515383 (+)
FVB/NJ MGP_FVBNJ_G0025420
 protein coding gene Chr2:29378090-29391467 (+)
LP/J MGP_LPJ_G0025544
 protein coding gene Chr2:30938807-30951518 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025451
 protein coding gene Chr2:32852419-32865187 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026089
 protein coding gene Chr2:30678118-30690720 (+)
PWK/PhJ MGP_PWKPhJ_G0024557
 protein coding gene Chr2:29408763-29421496 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024357
 protein coding gene Chr2:30832777-30845360 (+)
WSB/EiJ MGP_WSBEiJ_G0024878
 protein coding gene Chr2:30855523-30868126 (+)



Homology
more
  • Human Ortholog
    ST6GALNAC4, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ST6GALNAC4, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
  • Synonyms
    IV, SIAT3C, SIAT3-C, SIAT7D, SIAT7-D, ST6GalNAc, ST6GALNACIV
  • Links
    NCBI Gene ID: 27090
    neXtProt AC: NX_Q9H4F1
    UniProt: Q9H4F1

  • Chr Location
    9q34.11; chr9:127907886-127917041 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    6 phenotype references
Mice homozygous for a null allele exhibit no abnormal phenotype. Double homozygotes lacking St6galnac3 and St6galnac4 exhibit lymph node hemorrhage associated with structural disruption of high endothelial venule.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    832
  • Tissues
    110
  • cDNA Data
    67
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000079442 Ensembl Gene Model | MGI Sequence Detail 12604 C57BL/6J ±  kb
transcript ENSMUST00000102818 Ensembl | MGI Sequence Detail 3626 Not Applicable  
polypeptide ENSMUSP00000099882 Ensembl | MGI Sequence Detail 302 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000015690 alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase
    (term hierarchy)
  • EC
    2.4.3.7
  • InterPro Domains
    IPR001675 Glycosyl transferase family 29
    IPR038578 GT29-like superfamiliy
Molecular
Reagents
less
  • All nucleic 68
    cDNA 67
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:54623 Lee YC, et al., Molecular cloning and functional expression of two members of mouse NeuAcalpha2, 3 Galbeta1,3GalNAc GalNAcalpha2,6-sialyltransferase family, ST6GalNAc III and IV. J Biol Chem. 1999 Apr 23;274(17):11958-67
  • Latest
    J:340690 Fuseya S, et al., Reduction in disialyl-T antigen levels in mice deficient for both St6galnac3 and St6galnac4 results in blood filling of lymph nodes. Sci Rep. 2023 Jun 29;13(1):10582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory