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St6galnac3 Gene Detail
Summary
  • Symbol
    St6galnac3
  • Name
    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
  • Synonyms
    Siat7c, ST6GalNAc III
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341828
    NCBI Gene: 20447
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:152903911-153430804 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 77.82 cM, cytoband H4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3098 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341828
 protein coding gene Chr3:152903903-153430811 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027996
 protein coding gene Chr3:157108087-157673113 (-)
A/J MGP_AJ_G0027955
 protein coding gene Chr3:151399613-151937317 (-)
AKR/J MGP_AKRJ_G0027921
 protein coding gene Chr3:155415084-155996386 (-)
BALB/cJ MGP_BALBcJ_G0027967
 protein coding gene Chr3:151207863-151745220 (-)
C3H/HeJ MGP_C3HHeJ_G0027697
 protein coding gene Chr3:155823725-156373200 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028410
 protein coding gene Chr3:162244940-162813924 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025748
 protein coding gene Chr3:146202419-146719769 (-)
CAST/EiJ MGP_CASTEiJ_G0027150
 protein coding gene Chr3:155916425-156477213 (-)
CBA/J MGP_CBAJ_G0027672
 protein coding gene Chr3:168090393-168679769 (-)
DBA/2J MGP_DBA2J_G0027812
 protein coding gene Chr3:150494049-151022750 (-)
FVB/NJ MGP_FVBNJ_G0027779
 protein coding gene Chr3:147864561-148392999 (-)
LP/J MGP_LPJ_G0027923
 protein coding gene Chr3:158451965-159012425 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027812
 protein coding gene Chr3:176597389-177159172 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028469
 protein coding gene Chr3:155081762-155636277 (-)
PWK/PhJ MGP_PWKPhJ_G0026873
 protein coding gene Chr3:150398852-150934597 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026701
 protein coding gene Chr3:153233840-153801299 (-)
WSB/EiJ MGP_WSBEiJ_G0027230
 protein coding gene Chr3:156068085-156624695 (-)



Homology
more
  • Human Ortholog
    ST6GALNAC3, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ST6GALNAC3, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
  • Synonyms
    PRO7177, SIAT7C, ST6GALNACIII, STY
  • Links
    NCBI Gene ID: 256435
    neXtProt AC: NX_Q8NDV1
    UniProt: Q8NDV1

  • Chr Location
    1p31.1; chr1:76074746-76637339 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit no abnormal phenotype. Double homozygotes lacking St6galnac3 and St6galnac4 exhibit lymph node hemorrhage associated with structural disruption of high endothelial venule.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    835
  • Tissues
    112
  • cDNA Data
    9
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20447 NCBI Gene Model | MGI Sequence Detail 526894 C57BL/6J ±  kb
    transcript NR_184541 RefSeq | MGI Sequence Detail 3086 C57BL/6  
    polypeptide Q9WUV2 UniProt | EBI | MGI Sequence Detail 305 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:54623 Lee YC, et al., Molecular cloning and functional expression of two members of mouse NeuAcalpha2, 3 Galbeta1,3GalNAc GalNAcalpha2,6-sialyltransferase family, ST6GalNAc III and IV. J Biol Chem. 1999 Apr 23;274(17):11958-67
    • Latest
      J:340690 Fuseya S, et al., Reduction in disialyl-T antigen levels in mice deficient for both St6galnac3 and St6galnac4 results in blood filling of lymph nodes. Sci Rep. 2023 Jun 29;13(1):10582
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory