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Tnfrsf10b Gene Detail
Summary
  • Symbol
    Tnfrsf10b
  • Name
    tumor necrosis factor receptor superfamily, member 10b
  • Synonyms
    DR5, KILLER, Killer/Dr5, Ly98, TRAILR2, TRAIL-R2, Trail Receptor, TRICK2A, TRICK2B, TRICKB
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341090
    NCBI Gene: 21933
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:70004921-70021860 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 36.10 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    95 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341090
 protein coding gene Chr14:70004921-70021860 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021525
 protein coding gene Chr14:64352561-64372678 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0021460
 protein coding gene Chr14:64911568-64930616 (+)
BALB/cJ MGP_BALBcJ_G0021490
 protein coding gene Chr14:62782621-62799296 (+)
C3H/HeJ MGP_C3HHeJ_G0021267
 protein coding gene Chr14:64630833-64646624 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021929
 protein coding gene Chr14:67252475-67270642 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019469
 protein coding gene Chr14:60861326-60873151 (+)
CAST/EiJ MGP_CASTEiJ_G0020784
 protein coding gene Chr14:61185717-61203614 (+)
CBA/J MGP_CBAJ_G0021234
 protein coding gene Chr14:69361241-69383148 (+)
DBA/2J MGP_DBA2J_G0021357
 protein coding gene Chr14:62405487-62418436 (+)
FVB/NJ MGP_FVBNJ_G0021336
 protein coding gene Chr14:61827543-61846710 (+)
LP/J MGP_LPJ_G0021427
 protein coding gene Chr14:65612918-65634687 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021365
 protein coding gene Chr14:68297350-68317492 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021952
 protein coding gene Chr14:64169724-64189453 (+)
PWK/PhJ MGP_PWKPhJ_G0020528
 protein coding gene Chr14:59157187-59174844 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020361
 protein coding gene Chr14:60095098-60111704 (+)
WSB/EiJ MGP_WSBEiJ_G0020837
 protein coding gene Chr14:64472733-64489442 (+)



Homology
more
  • Human Ortholog
    TNFRSF10A, TNF receptor superfamily member 10a
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFRSF10A, TNF receptor superfamily member 10a
  • Synonyms
    APO2, CD261, DR4, TRAILR1, TRAILR-1
  • Links
    NCBI Gene ID: 8797
    neXtProt AC: NX_O00220
    UniProt: O00220

  • Chr Location
    8p21.3; chr8:23190452-23225102 (-)  GRCh38
  • Human Ortholog
    TNFRSF10B, TNF receptor superfamily member 10b
  • Synonyms
    CD262, DR5, KILLER, KILLER/DR5, TRAILR2, TRAIL-R2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9
  • Links
    NCBI Gene ID: 8795
    neXtProt AC: NX_O14763
    UniProt: O14763

  • Chr Location
    8p21.3; chr8:23020133-23069031 (-)  GRCh38
  • Human Ortholog
    TNFRSF10C, TNF receptor superfamily member 10c
  • Synonyms
    CD263, DCR1, DCR1-TNFR, LIT, TRAILR3, TRAIL-R3, TRID
  • Links
    NCBI Gene ID: 8794
    neXtProt AC: NX_O14798
    UniProt: O14798

  • Chr Location
    8p21.3; chr8:23102921-23117445 (+)  GRCh38
  • Human Ortholog
    TNFRSF10D, TNF receptor superfamily member 10d
  • Synonyms
    CD264, DCR2, TRAILR4, TRAIL-R4, TRUNDD
  • Links
    NCBI Gene ID: 8793
    neXtProt AC: NX_Q9UBN6
    UniProt: Q9UBN6

  • Chr Location
    8p21.3; chr8:23135588-23164027 (-)  GRCh38
Human Diseases
more
  • Diseases
    7 with human TNFRSF10A,TNFRSF10B associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit enhanced innate immune responses, including increased clearance of cytomegalovirus and increased levels of IL-12, IFN-alpha and IFN-gamma after viral infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    17
  • cDNA Data
    11
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21933 NCBI Gene Model | MGI Sequence Detail 16940 C57BL/6J ±  kb
    transcript NM_020275 RefSeq | MGI Sequence Detail 3197 C57BL/6  
    polypeptide Q9QZM4 UniProt | EBI | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR000488 Death domain
      IPR011029 Death-like domain superfamily
      IPR001368 TNFR/NGFR cysteine-rich region
      IPR034024 Tumor necrosis factor receptor 10, N-terminal
      IPR020465 Tumour necrosis factor receptor 10
      IPR034029 Tumour necrosis factor receptor 10A/B, death domain
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 12
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 9
      Gene Ontology 6
      Phenotypes 40
    • Earliest
      J:55627 Wu GS, et al., Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor. Cancer Res. 1999 Jun 15;59(12):2770-5
    • Latest
      J:344416 Liu J, et al., Death receptor 5 is required for intestinal stem cell activity during intestinal epithelial renewal at homoeostasis. Cell Death Dis. 2024 Jan 10;15(1):27
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory