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Padi4 Gene Detail
Summary
  • Symbol
    Padi4
  • Name
    peptidyl arginine deiminase, type IV
  • Synonyms
    Pad4, PAD type IV, Pdi4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338898
    NCBI Gene: 18602
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:140473176-140501547 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 72.34 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    267 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338898
 protein coding gene Chr4:140472819-140501547 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029029
 protein coding gene Chr4:143715664-143751314 (-)
A/J MGP_AJ_G0028988
 protein coding gene Chr4:137493337-137522116 (-)
AKR/J MGP_AKRJ_G0028940
 protein coding gene Chr4:141466390-141497306 (-)
BALB/cJ MGP_BALBcJ_G0029012
 protein coding gene Chr4:138188041-138222822 (-)
C3H/HeJ MGP_C3HHeJ_G0028726
 protein coding gene Chr4:141850423-141882923 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029453
 protein coding gene Chr4:148765385-148798067 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026724
 protein coding gene Chr4:130429337-130457243 (-)
CAST/EiJ MGP_CASTEiJ_G0028158
 protein coding gene Chr4:140086927-140120719 (-)
CBA/J MGP_CBAJ_G0028690
 protein coding gene Chr4:153008499-153053399 (-)
DBA/2J MGP_DBA2J_G0028840
 protein coding gene Chr4:137895177-137929759 (-)
FVB/NJ MGP_FVBNJ_G0028807
 protein coding gene Chr4:136988287-137019184 (-)
LP/J MGP_LPJ_G0028939
 protein coding gene Chr4:143752796-143784779 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028833
 protein coding gene Chr4:156932554-156965357 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029491
 protein coding gene Chr4:141992802-142023558 (-)
PWK/PhJ MGP_PWKPhJ_G0027879
 protein coding gene Chr4:134769996-134799330 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027704
 protein coding gene Chr4:137814486-137855938 (-)
WSB/EiJ MGP_WSBEiJ_G0028236
 protein coding gene Chr4:142277192-142308580 (-)



Homology
more
  • Human Ortholog
    PADI4, peptidyl arginine deiminase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PADI4, peptidyl arginine deiminase 4
  • Synonyms
    PAD, PAD4, PADI5, PDI4, PDI5
  • Links
    NCBI Gene ID: 23569
    neXtProt AC: NX_Q9UM07
    UniProt: Q9UM07

  • Chr Location
    1p36.13; chr1:17308195-17364004 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 5 alleles in 4 genetic backgrounds
    87 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice are viable albeit reduced number than expected were born from heterozygous crosses, and shows decreased antibacterial immune responses. Mice homozygous for a different knock-out allele exhibit decreased weight loss in response to viral infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    808
  • Tissues
    102
  • cDNA Data
    24
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025330 Ensembl Gene Model | MGI Sequence Detail 28372 C57BL/6J ±  kb
    transcript ENSMUST00000026381 Ensembl | MGI Sequence Detail 2316 Not Applicable  
    polypeptide ENSMUSP00000026381 Ensembl | MGI Sequence Detail 666 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 25
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 131
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 87
    • Earliest
      J:53035 Rus'd AA, et al., Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse. Eur J Biochem. 1999 Feb;259(3):660-9
    • Latest
      J:345055 Zhang C, et al., The scaffold of neutrophil extracellular traps promotes CCA progression and modulates angiogenesis via ITGAV/NFkappaB. Cell Commun Signal. 2024 Feb 8;22(1):103
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory