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Btrc Gene Detail
Summary
  • Symbol
    Btrc
  • Name
    beta-transducin repeat containing protein
  • Synonyms
    beta-TrCP, Beta-Trcp1, Fbw1a, SCF b-TRCP, Slimb
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338871
    NCBI Gene: 12234
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:45352173-45518452 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 38.75 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    835 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338871
 protein coding gene Chr19:45352119-45521782 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025187
 protein coding gene Chr19:44952244-45138201 (+)
A/J MGP_AJ_G0025164
 protein coding gene Chr19:42762886-42934932 (+)
AKR/J MGP_AKRJ_G0025132
 protein coding gene Chr19:44137059-44315789 (+)
BALB/cJ MGP_BALBcJ_G0025158
 protein coding gene Chr19:42812388-42986624 (+)
C3H/HeJ MGP_C3HHeJ_G0024918
 protein coding gene Chr19:44323794-44495039 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025601
 protein coding gene Chr19:46090453-46268501 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023015
 protein coding gene Chr19:42017219-42187671 (+)
CAST/EiJ MGP_CASTEiJ_G0024383
 protein coding gene Chr19:44051756-44234672 (+)
CBA/J MGP_CBAJ_G0024898
 protein coding gene Chr19:48394796-48583957 (+)
DBA/2J MGP_DBA2J_G0025030
 protein coding gene Chr19:42575615-42746148 (+)
FVB/NJ MGP_FVBNJ_G0024991
 protein coding gene Chr19:42356450-42528254 (+)
LP/J MGP_LPJ_G0025116
 protein coding gene Chr19:44877456-45054320 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025022
 protein coding gene Chr19:47733713-47929506 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025659
 protein coding gene Chr19:44216355-44390159 (+)
PWK/PhJ MGP_PWKPhJ_G0024132
 protein coding gene Chr19:42494717-42668995 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023936
 protein coding gene Chr19:42892633-43077497 (+)
WSB/EiJ MGP_WSBEiJ_G0024453
 protein coding gene Chr19:44372965-44546907 (+)



Homology
more
  • Human Ortholog
    BTRC, beta-transducin repeat containing E3 ubiquitin protein ligase
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BTRC, beta-transducin repeat containing E3 ubiquitin protein ligase
  • Synonyms
    betaTrCP, BETA-TRCP, bTrCP, bTrCP1, FBW1A, FBXW1, FBXW1A, FWD1
  • Links
    NCBI Gene ID: 8945
    neXtProt AC: NX_Q9Y297
    UniProt: Q9Y297

  • Chr Location
    10q24.32; chr10:101354033-101557321 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryonic fibroblasts from homozygotes show an increase in polyploidy and apoptosis and decreased cell proliferation. In a second allele, homozygous mutation results in reduced male fertility and abnormal male meiosis with oligozoospermia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    67
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1023
  • Tissues
    223
  • cDNA Data
    20
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025217 Ensembl Gene Model | MGI Sequence Detail 166280 C57BL/6J ±  kb
    transcript ENSMUST00000065601 Ensembl | MGI Sequence Detail 2978 Not Applicable  
    polypeptide ENSMUSP00000070728 Ensembl | MGI Sequence Detail 605 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 20
      Primer pair 3

      Microarray probesets 4
    References
    more
    • Summaries
      All 104
      Developmental Gene Expression 15
      Gene Ontology 21
      Phenotypes 26
    • Earliest
      J:54317 Yaron A, et al., Identification of the receptor component of the IkappaBalpha-ubiquitin ligase. Nature. 1998 Dec 10;396(6711):590-4
    • Latest
      J:334109 Cova G, et al., Combinatorial effects on gene expression at the Lbx1/Fgf8 locus resolve split-hand/foot malformation type 3. Nat Commun. 2023 Mar 17;14(1):1475
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory