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Kcnq3 Gene Detail
Summary
  • Symbol
    Kcnq3
  • Name
    potassium voltage-gated channel, subfamily Q, member 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336181
    NCBI Gene: 110862
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:65858236-66158491 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 29.16 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3015 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336181
 protein coding gene Chr15:65858223-66158491 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021903
 protein coding gene Chr15:65487279-65784477 (-)
A/J MGP_AJ_G0021862
 protein coding gene Chr15:62993853-63287071 (-)
AKR/J MGP_AKRJ_G0021844
 protein coding gene Chr15:64750809-65037025 (-)
BALB/cJ MGP_BALBcJ_G0021869
 protein coding gene Chr15:63177755-63473610 (-)
C3H/HeJ MGP_C3HHeJ_G0021642
 protein coding gene Chr15:64864951-65162469 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022308
 protein coding gene Chr15:68027185-68337231 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019845
 protein coding gene Chr15:59795391-60079849 (-)
CAST/EiJ MGP_CASTEiJ_G0021161
 protein coding gene Chr15:65495911-65808647 (-)
CBA/J MGP_CBAJ_G0021608
 protein coding gene Chr15:70303545-70617314 (-)
DBA/2J MGP_DBA2J_G0021733
 protein coding gene Chr15:62786028-63081022 (-)
FVB/NJ MGP_FVBNJ_G0021715
 protein coding gene Chr15:61827453-62111646 (-)
LP/J MGP_LPJ_G0021805
 protein coding gene Chr15:65365449-65674809 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021738
 protein coding gene Chr15:75394261-75701060 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022330
 protein coding gene Chr15:65123264-65420385 (-)
PWK/PhJ MGP_PWKPhJ_G0020902
 protein coding gene Chr15:62865449-63161849 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020743
 protein coding gene Chr15:64964741-65265087 (-)
WSB/EiJ MGP_WSBEiJ_G0021213
 protein coding gene Chr15:65090542-65392869 (-)



Homology
more
  • Human Ortholog
    KCNQ3, potassium voltage-gated channel subfamily Q member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNQ3, potassium voltage-gated channel subfamily Q member 3
  • Synonyms
    BFNC2, EBN2, KV7.3
  • Links
    NCBI Gene ID: 3786
    neXtProt AC: NX_O43525
    UniProt: O43525

  • Chr Location
    8q24.22; chr8:132120861-132481095 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Kcnq3 mouse models; 2 with human KCNQ3 associations

Human Disease Mouse Models
      
IDs
 View 5 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 4 alleles in 7 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit abnormal apamin-insensitive afterhyperpolarization currents in granule cells, but not pyramidal cells, of the hippocampus. Mice homozygous for a knock-in allele exhibit spontaneous seizures and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    83
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    785
  • Tissues
    23
  • cDNA Data
    7
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056258 Ensembl Gene Model | MGI Sequence Detail 300256 C57BL/6J ±  kb
    transcript ENSMUST00000070256 Ensembl | MGI Sequence Detail 11824 Not Applicable  
    polypeptide ENSMUSP00000063380 Ensembl | MGI Sequence Detail 873 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 8
      Primer pair 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 12
      Diseases 2
      Gene Ontology 20
      Phenotypes 31
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:326958 Sapir T, et al., Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex. Nat Commun. 2022 Jul 21;13(1):4209
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory