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Minpp1 Gene Detail
Summary
  • Symbol
    Minpp1
  • Name
    multiple inositol polyphosphate histidine phosphatase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336159
    NCBI Gene: 17330
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:32463169-32492764 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 27.25 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336159
 protein coding gene Chr19:32463169-32492770 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025040
 protein coding gene Chr19:31119090-31149718 (+)
A/J MGP_AJ_G0025017
 protein coding gene Chr19:29569281-29601240 (+)
AKR/J MGP_AKRJ_G0024985
 protein coding gene Chr19:30603318-30634262 (+)
BALB/cJ MGP_BALBcJ_G0025016
 protein coding gene Chr19:29621833-29651179 (+)
C3H/HeJ MGP_C3HHeJ_G0024772
 protein coding gene Chr19:30596306-30624628 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025457
 protein coding gene Chr19:31982509-32015368 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022876
 protein coding gene Chr19:29474637-29506522 (+)
CAST/EiJ MGP_CASTEiJ_G0024243
 protein coding gene Chr19:30498894-30529401 (+)
CBA/J MGP_CBAJ_G0024750
 protein coding gene Chr19:33471745-33507108 (+)
DBA/2J MGP_DBA2J_G0024882
 protein coding gene Chr19:29493502-29522636 (+)
FVB/NJ MGP_FVBNJ_G0024844
 protein coding gene Chr19:29317925-29347056 (+)
LP/J MGP_LPJ_G0024967
 protein coding gene Chr19:31121044-31150068 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024871
 protein coding gene Chr19:33330547-33359559 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025512
 protein coding gene Chr19:30653171-30685156 (+)
PWK/PhJ MGP_PWKPhJ_G0023991
 protein coding gene Chr19:29188977-29217947 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023795
 protein coding gene Chr19:29987521-30014734 (+)
WSB/EiJ MGP_WSBEiJ_G0024309
 protein coding gene Chr19:30690198-30720629 (+)



Homology
more
  • Human Ortholog
    MINPP1, multiple inositol-polyphosphate phosphatase 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MINPP1, multiple inositol-polyphosphate phosphatase 1
  • Synonyms
    HIPER1, MINPP2, MIPP, PCH16
  • Links
    NCBI Gene ID: 9562
    neXtProt AC: NX_Q9UNW1
    UniProt: Q9UNW1

  • Chr Location
    10q23.2; chr10:87504875-87553461 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human MINPP1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation exhibit no discernable phenotype. Another null allele shows a 10% decrease in brain weight due to reduced cortical thickness and decreased intracellular free calcium levels in E14.5 neural progenitors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    832
  • Tissues
    100
  • cDNA Data
    61
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024896 Ensembl Gene Model | MGI Sequence Detail 29596 C57BL/6J ±  kb
    transcript ENSMUST00000025827 Ensembl | MGI Sequence Detail 2613 Not Applicable  
    polypeptide ENSMUSP00000025827 Ensembl | MGI Sequence Detail 481 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 66
      Genomic 1
      cDNA 64
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2147435
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 7
    • Earliest
      J:54008 Chi H, et al., Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19. Genomics. 1999 Mar 15;56(3):324-36
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory