About   Help   FAQ
Rasgrp2 Gene Detail
Summary
  • Symbol
    Rasgrp2
  • Name
    RAS, guanyl releasing protein 2
  • Synonyms
    Caldaggef1, CalDAG-GEFI
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333849
    NCBI Gene: 19395
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6449370-6465246 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.58 cM, cytoband A
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    53 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333849
 protein coding gene Chr19:6449038-6465246 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024763
 protein coding gene Chr19:3454636-3471965 (+)
A/J MGP_AJ_G0024729
 protein coding gene Chr19:3265995-3281867 (+)
AKR/J MGP_AKRJ_G0024702
 protein coding gene Chr19:3363321-3379224 (+)
BALB/cJ MGP_BALBcJ_G0024729
 protein coding gene Chr19:3263256-3279167 (+)
C3H/HeJ MGP_C3HHeJ_G0024497
 protein coding gene Chr19:3383855-3399735 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025175
 protein coding gene Chr19:3505973-3521853 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022609
 protein coding gene Chr19:3188950-3204809 (+)
CAST/EiJ MGP_CASTEiJ_G0023969
 protein coding gene Chr19:3409378-3425252 (+)
CBA/J MGP_CBAJ_G0024469
 protein coding gene Chr19:3677507-3693372 (+)
DBA/2J MGP_DBA2J_G0024596
 protein coding gene Chr19:3253544-3269418 (+)
FVB/NJ MGP_FVBNJ_G0024562
 protein coding gene Chr19:3270239-3286107 (+)
LP/J MGP_LPJ_G0024682
 protein coding gene Chr19:3419089-3435001 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024591
 protein coding gene Chr19:3501135-3516898 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025223
 protein coding gene Chr19:3388476-3404351 (+)
PWK/PhJ MGP_PWKPhJ_G0023715
 protein coding gene Chr19:3288004-3304005 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023520
 protein coding gene Chr19:3347554-3363528 (+)
WSB/EiJ MGP_WSBEiJ_G0024031
 protein coding gene Chr19:3403194-3420396 (+)



Homology
more
  • Human Ortholog
    RASGRP2, RAS guanyl releasing protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RASGRP2, RAS guanyl releasing protein 2
  • Synonyms
    CALDAG-GEFI, CDC25L
  • Links
    NCBI Gene ID: 10235
    neXtProt AC: NX_Q7LDG7
    UniProt: Q7LDG7

  • Chr Location
    11q13.1; chr11:64726911-64745456 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rasgrp2 mouse models; 1 with human RASGRP2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele do not undergo spontaneous hemorrhaging but exhibit impaired platelet aggregation, resistance to collagen-induced thrombosis, and increased bleeding times after tail transection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    4
  • cDNA Data
    9
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032946 Ensembl Gene Model | MGI Sequence Detail 15877 C57BL/6J ±  kb
transcript ENSMUST00000113476 Ensembl | MGI Sequence Detail 2296 Not Applicable  
polypeptide ENSMUSP00000109104 Ensembl | MGI Sequence Detail 608 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000013759 RAS guanyl-releasing protein 2
    (term hierarchy)
  • InterPro Domains
    IPR046349 C1-like domain superfamily
    IPR018247 EF-Hand 1, calcium-binding site
    IPR002048 EF-hand domain
    IPR011992 EF-hand domain pair
    IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
    IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily
    IPR023578 Ras guanine nucleotide exchange factor domain superfamily
    IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
    IPR008937 Ras-like guanine nucleotide exchange factor
    IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
Molecular
Reagents
less
  • All nucleic 12
    cDNA 9
    Primer pair 3

    Microarray probesets 6
References
more
  • Summaries
    All 63
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 7
    Phenotypes 26
  • Earliest
    J:52725 Kedra D, et al., The germinal center kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13. Hum Genet. 1997 Oct;100(5-6):611-9
  • Latest
    J:322215 Crittenden JR, et al., CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors. Neurobiol Dis. 2021 Oct;158:105473
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory