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S1pr4 Gene Detail
Summary
  • Symbol
    S1pr4
  • Name
    sphingosine-1-phosphate receptor 4
  • Synonyms
    Edg6, lpC1, S1P4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333809
    NCBI Gene: 13611
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:81333581-81335966 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333809
 protein coding gene Chr10:81333579-81335971 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017562
 protein coding gene Chr10:82223540-82225927 (-)
A/J MGP_AJ_G0017540
 protein coding gene Chr10:79303206-79305593 (-)
AKR/J MGP_AKRJ_G0017501
 protein coding gene Chr10:81478821-81481208 (-)
BALB/cJ MGP_BALBcJ_G0017502
 protein coding gene Chr10:79526226-79528596 (-)
C3H/HeJ MGP_C3HHeJ_G0017325
 protein coding gene Chr10:81581932-81584319 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017956
 protein coding gene Chr10:85042706-85044890 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015645
 protein coding gene Chr10:75501547-75503931 (-)
CAST/EiJ MGP_CASTEiJ_G0016892
 protein coding gene Chr10:81822713-81825100 (-)
CBA/J MGP_CBAJ_G0017297
 protein coding gene Chr10:88376721-88379105 (-)
DBA/2J MGP_DBA2J_G0017403
 protein coding gene Chr10:78508942-78511329 (-)
FVB/NJ MGP_FVBNJ_G0017397
 protein coding gene Chr10:77768852-77771239 (-)
LP/J MGP_LPJ_G0017474
 protein coding gene Chr10:82670810-82673197 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017423
 protein coding gene Chr10:90204232-90206619 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017997
 protein coding gene Chr10:81491595-81493982 (-)
PWK/PhJ MGP_PWKPhJ_G0016673
 protein coding gene Chr10:78413695-78416082 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016463
 protein coding gene Chr10:80444503-80446897 (-)
WSB/EiJ MGP_WSBEiJ_G0016952
 protein coding gene Chr10:81537905-81540292 (-)



Homology
more
  • Human Ortholog
    S1PR4, sphingosine-1-phosphate receptor 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    S1PR4, sphingosine-1-phosphate receptor 4
  • Synonyms
    EDG6, LPC1, S1P4, SLP4
  • Links
    NCBI Gene ID: 8698
    neXtProt AC: NX_O95977
    UniProt: O95977

  • Chr Location
    19p13.3; chr19:3172346-3180332 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in mid-gestation embryonic lethality. Heterozygotes exhibit decreased prepulse inhibition.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    883
  • Tissues
    102
  • cDNA Data
    14
  • Literature Summary
    12
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044199 Ensembl Gene Model | MGI Sequence Detail 2386 C57BL/6J ±  kb
transcript ENSMUST00000053646 Ensembl | MGI Sequence Detail 2386 Not Applicable  
polypeptide ENSMUSP00000050412 Ensembl | MGI Sequence Detail 386 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 14
    Primer pair 5
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 64
    Developmental Gene Expression 12
    Gene Ontology 6
    Phenotypes 22
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:341158 Kurano M, et al., Apolipoprotein M bound sphingosine 1-phosphate suppresses NETosis through activating S1P1 and S1P4. Biomed Pharmacother. 2023 Oct;166:115400
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory