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Epn2 Gene Detail
Summary
  • Symbol
    Epn2
  • Name
    epsin 2
  • Synonyms
    9530051D10Rik, Ibp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333766
    NCBI Gene: 13855
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:61408075-61470513 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 37.96 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    210 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333766
 protein coding gene Chr11:61406709-61470560 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018442
 protein coding gene Chr11:61481835-61543484 (-)
A/J MGP_AJ_G0018411
 protein coding gene Chr11:59211822-59273695 (-)
AKR/J MGP_AKRJ_G0018381
 protein coding gene Chr11:61053689-61115306 (-)
BALB/cJ MGP_BALBcJ_G0018382
 protein coding gene Chr11:59517291-59579894 (-)
C3H/HeJ MGP_C3HHeJ_G0018195
 protein coding gene Chr11:61035770-61098529 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018834
 protein coding gene Chr11:63432312-63497256 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016480
 protein coding gene Chr11:56337659-56395693 (-)
CAST/EiJ MGP_CASTEiJ_G0017752
 protein coding gene Chr11:61140461-61204740 (-)
CBA/J MGP_CBAJ_G0018169
 protein coding gene Chr11:66180536-66244590 (-)
DBA/2J MGP_DBA2J_G0018278
 protein coding gene Chr11:58785674-58847459 (-)
FVB/NJ MGP_FVBNJ_G0018269
 protein coding gene Chr11:58470455-58532097 (-)
LP/J MGP_LPJ_G0018351
 protein coding gene Chr11:62052243-62115082 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018293
 protein coding gene Chr11:67196548-67259794 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018875
 protein coding gene Chr11:61188971-61252032 (-)
PWK/PhJ MGP_PWKPhJ_G0017525
 protein coding gene Chr11:59381176-59447352 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017315
 protein coding gene Chr11:61012644-61074439 (-)
WSB/EiJ MGP_WSBEiJ_G0017804
 protein coding gene Chr11:60795158-60856816 (-)



Homology
more
  • Human Ortholog
    EPN2, epsin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPN2, epsin 2
  • Synonyms
    EHB21
  • Links
    NCBI Gene ID: 22905
    neXtProt AC: NX_O95208
    UniProt: O95208

  • Chr Location
    17p11.2; chr17:19215615-19336715 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    30 phenotypes from multigenic genotypes
    7 images
    23 phenotype references
Mice homozygous for a null mutation are viable and fertile with no gross abnormalities. Mice homozygous null for both Epn1 and Epn2 display defects in angiogenic vascular remodeling, impaired somitogenesis and extensive cell death in the nervous tissue, resulting in lethality during organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    15
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001036 Ensembl Gene Model | MGI Sequence Detail 62439 C57BL/6J ±  kb
transcript ENSMUST00000179936 Ensembl | MGI Sequence Detail 4452 Not Applicable  
polypeptide ENSMUSP00000136950 Ensembl | MGI Sequence Detail 640 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 6
Other
Accession IDs
less
MGI:1925919, MGI:2144024
References
more
  • Summaries
    All 52
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 23
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:325471 Wang B, et al., Disruption of USP9X in macrophages promotes foam cell formation and atherosclerosis. J Clin Invest. 2022 May 16;132(10):e154217
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory