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Bnip3l Gene Detail
Summary
  • Symbol
    Bnip3l
  • Name
    BCL2/adenovirus E1B interacting protein 3-like
  • Synonyms
    D14Ertd719e, Nip3L, Nix
  • Feature Type
    protein coding gene
  • IDs
    MGI:1332659
    NCBI Gene: 12177
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:67222688-67246326 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 34.60 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    78 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1332659
 protein coding gene Chr14:67222688-67246580 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021501
 protein coding gene Chr14:61693741-61719592 (-)
A/J MGP_AJ_G0021460
 protein coding gene Chr14:60198638-60225618 (-)
AKR/J MGP_AKRJ_G0021436
 protein coding gene Chr14:62273317-62297364 (-)
BALB/cJ MGP_BALBcJ_G0021466
 protein coding gene Chr14:60200487-60234572 (-)
C3H/HeJ MGP_C3HHeJ_G0021243
 protein coding gene Chr14:62003992-62027548 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021905
 protein coding gene Chr14:64506197-64535605 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019445
 protein coding gene Chr14:58123547-58147199 (-)
CAST/EiJ MGP_CASTEiJ_G0020760
 protein coding gene Chr14:58473277-58499991 (-)
CBA/J MGP_CBAJ_G0021210
 protein coding gene Chr14:66489866-66519627 (-)
DBA/2J MGP_DBA2J_G0021333
 protein coding gene Chr14:59854493-59878346 (-)
FVB/NJ MGP_FVBNJ_G0021312
 protein coding gene Chr14:59257636-59283648 (-)
LP/J MGP_LPJ_G0021408
 protein coding gene Chr14:62745926-62772174 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021341
 protein coding gene Chr14:65506087-65530907 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021928
 protein coding gene Chr14:61501384-61527488 (-)
PWK/PhJ MGP_PWKPhJ_G0020504
 protein coding gene Chr14:56594420-56619319 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020337
 protein coding gene Chr14:57459898-57489228 (-)
WSB/EiJ MGP_WSBEiJ_G0020813
 protein coding gene Chr14:61820592-61850652 (-)



Homology
more
  • Human Ortholog
    BNIP3L, BCL2 interacting protein 3 like
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BNIP3L, BCL2 interacting protein 3 like
  • Synonyms
    BNIP3a, NIP3L, NIX
  • Links
    NCBI Gene ID: 665
    neXtProt AC: NX_O60238
    UniProt: O60238

  • Chr Location
    8p21.2; chr8:26383054-26505636 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 4 alleles in 5 genetic backgrounds
    9 phenotypes from multigenic genotypes
    2 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit abnormal morphology, decreased numbers and increased fragility of reticulocyte and erythcrocyte.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    864
  • Tissues
    131
  • cDNA Data
    20
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022051 Ensembl Gene Model | MGI Sequence Detail 23639 C57BL/6J ±  kb
    transcript ENSMUST00000022634 Ensembl | MGI Sequence Detail 3238 Not Applicable  
    polypeptide ENSMUSP00000022634 Ensembl | MGI Sequence Detail 218 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 21
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1289182, MGI:2145873
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 13
      Gene Ontology 12
      Phenotypes 28
    • Earliest
      J:51799 Chen G, et al., Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. J Biol Chem. 1999 Jan 1;274(1):7-10
    • Latest
      J:329326 Marta C, et al., Mitochondrial function and intracellular distribution is severely affected in in vitro cultured mouse embryos. Sci Rep. 2022 Sep 27;12(1):16152
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory